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Original Research 
RMJ. 2018; 43(4): 631-634


Biochemical markers in patients co infected with hepatitis B and C resistant to interferon therapy

Naveeda Zagham, Sadaf Jafar, Qurat-ul-Ain Zia.

Abstract
Objective: To analyze the response of male and female Hepatitis C and B infected patients to interferon therapy.
Methodology: This experimental study was conducted at Center for Research in Experimental and Applied Medicine (CREAM), Department of Biochemistry and Molecular Biology, Army Medical College, Rawalpindi, Pakistan from January 3, to April 4, 2017. Blood samples of 15 seropositive, coinfected patients of hepatitis B and C were collected. The primers specific for STAT-1 were designed based on the previously available sequences on National Centre for Biotechnology Information (NCBI), using different dry lab tools like Electronic PCR and Oligo Calc. Primers are compared with other software.
Results: All 15 coinfected patients were resistant to pegylated interferon therapy, which was administered twice weekly for six months. Fifteen subjects were healthy individuals, which were taken as controls. Among 15 coinfected patients, 13 were male and 2 females. Among healthy individuals, 7 were males and 8 were females. Their ages ranged between 27-54 years. Liver function tests (serum ALT, serum ALP, and serum bilirubin), HBV and HCV genotyping and blood complete picture were performed.
Conclusion: Most of the co-infected patients showed raised bilirubin and ALT levels. The most significant affected age group was 38-39 years. Elderly male patients were affected more with the virus as compared to females.

Key words: Hepatitis, Interferon, viruses


 
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How to Cite this Article
Pubmed Style

Zagham N, Jafar S, Zia Q. Biochemical markers in patients co infected with hepatitis B and C resistant to interferon therapy. RMJ. 2018; 43(4): 631-634.


Web Style

Zagham N, Jafar S, Zia Q. Biochemical markers in patients co infected with hepatitis B and C resistant to interferon therapy. http://www.rmj.org.pk/?mno=284097 [Access: October 23, 2019].


AMA (American Medical Association) Style

Zagham N, Jafar S, Zia Q. Biochemical markers in patients co infected with hepatitis B and C resistant to interferon therapy. RMJ. 2018; 43(4): 631-634.



Vancouver/ICMJE Style

Zagham N, Jafar S, Zia Q. Biochemical markers in patients co infected with hepatitis B and C resistant to interferon therapy. RMJ. (2018), [cited October 23, 2019]; 43(4): 631-634.



Harvard Style

Zagham, N., Jafar, . S. & Zia, . Q. (2018) Biochemical markers in patients co infected with hepatitis B and C resistant to interferon therapy. RMJ, 43 (4), 631-634.



Turabian Style

Zagham, Naveeda, Sadaf Jafar, and Qurat-ul-Ain Zia. 2018. Biochemical markers in patients co infected with hepatitis B and C resistant to interferon therapy. Rawal Medical Journal, 43 (4), 631-634.



Chicago Style

Zagham, Naveeda, Sadaf Jafar, and Qurat-ul-Ain Zia. "Biochemical markers in patients co infected with hepatitis B and C resistant to interferon therapy." Rawal Medical Journal 43 (2018), 631-634.



MLA (The Modern Language Association) Style

Zagham, Naveeda, Sadaf Jafar, and Qurat-ul-Ain Zia. "Biochemical markers in patients co infected with hepatitis B and C resistant to interferon therapy." Rawal Medical Journal 43.4 (2018), 631-634. Print.



APA (American Psychological Association) Style

Zagham, N., Jafar, . S. & Zia, . Q. (2018) Biochemical markers in patients co infected with hepatitis B and C resistant to interferon therapy. Rawal Medical Journal, 43 (4), 631-634.








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