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Original Research 
RMJ. 2017; 42(4): 537-540


Protein content in gallstone patients can be a contributing factor in cholelithiasis

Naseem Aslam Channa, Amjad Hussain Memon, Amna Yasin Awan, Ali Mohammed Soomro, Lubna Noorani.

Abstract
Objective: To find out the protein contents as contributing factor in the cholelithiasis patients.
Methodology: The study was conducted during January 2016 to December 2016 at Institute of Biochemistry, University of Sindh, Jamshoro, Pakistan. A total number of 109 cholelithiasis patients admitted at Liaquat University Hospital, Jamshoro, Wali Bhai Rajputana Hospital, Hyderabad and Memon Charitable Hospital, Hyderabad, Pakistan and 294 age and gender matched control subjects were selected for the study. The serum samples of gallstone patients and control subjects were analyzed for the total protein contents by biuret kit method, gallstones recovered from the patients were also analyzed for the protein contents by Bradford method.
Results: Cholelithiasis patients showed that gallstone protein contents increased with increasing age. We found increased amount of protein contents in mixed composition of gallstones as compared to pure cholesterol gallstones. Serum protein contents were increased in patients with age group 31-45 years, followed by age group 16-30 years. Female cholelithiasis patients were found with increased serum protein contents (but within normal limits) as compared to male cholelithiasis patients. Increased protein contents were also observed in serum as well as in gallstone samples recovered from multiparous female patients in comparison to triparous female patients.
Conclusion: Protein may play a role in the pathogenesis of cholelithiasis.

Key words: Cholelithiasis, protein, gallstones, blood group, multiparous, triparous


 
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Pubmed Style

Naseem Aslam Channa, Amjad Hussain Memon, Amna Yasin Awan, Ali Mohammed Soomro, Lubna Noorani. Protein content in gallstone patients can be a contributing factor in cholelithiasis. RMJ. 2017; 42(4): 537-540.


Web Style

Naseem Aslam Channa, Amjad Hussain Memon, Amna Yasin Awan, Ali Mohammed Soomro, Lubna Noorani. Protein content in gallstone patients can be a contributing factor in cholelithiasis. http://www.rmj.org.pk/?mno=261238 [Access: January 16, 2019].


AMA (American Medical Association) Style

Naseem Aslam Channa, Amjad Hussain Memon, Amna Yasin Awan, Ali Mohammed Soomro, Lubna Noorani. Protein content in gallstone patients can be a contributing factor in cholelithiasis. RMJ. 2017; 42(4): 537-540.



Vancouver/ICMJE Style

Naseem Aslam Channa, Amjad Hussain Memon, Amna Yasin Awan, Ali Mohammed Soomro, Lubna Noorani. Protein content in gallstone patients can be a contributing factor in cholelithiasis. RMJ. (2017), [cited January 16, 2019]; 42(4): 537-540.



Harvard Style

Naseem Aslam Channa, Amjad Hussain Memon, Amna Yasin Awan, Ali Mohammed Soomro, Lubna Noorani (2017) Protein content in gallstone patients can be a contributing factor in cholelithiasis. RMJ, 42 (4), 537-540.



Turabian Style

Naseem Aslam Channa, Amjad Hussain Memon, Amna Yasin Awan, Ali Mohammed Soomro, Lubna Noorani. 2017. Protein content in gallstone patients can be a contributing factor in cholelithiasis. Rawal Medical Journal, 42 (4), 537-540.



Chicago Style

Naseem Aslam Channa, Amjad Hussain Memon, Amna Yasin Awan, Ali Mohammed Soomro, Lubna Noorani. "Protein content in gallstone patients can be a contributing factor in cholelithiasis." Rawal Medical Journal 42 (2017), 537-540.



MLA (The Modern Language Association) Style

Naseem Aslam Channa, Amjad Hussain Memon, Amna Yasin Awan, Ali Mohammed Soomro, Lubna Noorani. "Protein content in gallstone patients can be a contributing factor in cholelithiasis." Rawal Medical Journal 42.4 (2017), 537-540. Print.



APA (American Psychological Association) Style

Naseem Aslam Channa, Amjad Hussain Memon, Amna Yasin Awan, Ali Mohammed Soomro, Lubna Noorani (2017) Protein content in gallstone patients can be a contributing factor in cholelithiasis. Rawal Medical Journal, 42 (4), 537-540.








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