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Original Research Open Access
RMJ. 2017; 42(3): 299-301


Efficacy of metformin in maintaining euglycemia in patients with Gestational Diabetes Mellitus

Zain el Amir, Zainab Saifuddin, Shumaila Tanveer, Shazia Amir Khan.

Abstract
Objective: To determine efficacy of metformin in maintaining euglycemia in patients with GDM among women presenting in our institution.
Methodology: It was a prospective study conducted at the department of Obstetrics & Gynecology Railway teaching Hospital IIMCT, Rawalpindi from October 2014 to April 2015 and included 60 patients of 18-45 years of age at 10-32 weeks gestation in singleton pregnancy with fasting blood glucose levels > 6.1 mmol /L & 2 hours Post Prandial levels > 7.8 mml/L Metformin is started at a dose of 500mg daily and increased up to 2500mg daily. Aim was to keep fasting sugar level between 3.5 5.9 mmol/L & 2 hours post prandial < 7.8 mmol/L.
Results: The median daily dose of metformin was 1500 mg. The mean gestational age at delivery was 38.1 weeks. Neonatal hypoglycemia (glucose level < 1.6mmol/L ) was less common. The only adverse effects of metformin was GI upset (13.1 %) The results of postpartum questionnaire assessing acceptability of treatment among women treated with metformin alone, 65.6 % said they would chose metformin in subsequent pregnancy. The efficacy of metformin alone was 85.7%.
Conclusion: In women with gestational diabetes mellitus, metformin (alone or with supplemental insulin) is not associated with increased prenatal complications. The women preferred metformin to insulin treatment.

Key words: Metformin, Gestational diabetes, BMI, Insulin


 
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How to Cite this Article
Pubmed Style

Amir Ze, Saifuddin Z, Tanveer S, Khan SA. Efficacy of metformin in maintaining euglycemia in patients with Gestational Diabetes Mellitus. RMJ. 2017; 42(3): 299-301.


Web Style

Amir Ze, Saifuddin Z, Tanveer S, Khan SA. Efficacy of metformin in maintaining euglycemia in patients with Gestational Diabetes Mellitus. http://www.rmj.org.pk/?mno=252314 [Access: December 17, 2017].


AMA (American Medical Association) Style

Amir Ze, Saifuddin Z, Tanveer S, Khan SA. Efficacy of metformin in maintaining euglycemia in patients with Gestational Diabetes Mellitus. RMJ. 2017; 42(3): 299-301.



Vancouver/ICMJE Style

Amir Ze, Saifuddin Z, Tanveer S, Khan SA. Efficacy of metformin in maintaining euglycemia in patients with Gestational Diabetes Mellitus. RMJ. (2017), [cited December 17, 2017]; 42(3): 299-301.



Harvard Style

Amir, Z. e., Saifuddin, Z., Tanveer, S. & Khan, S. A. (2017) Efficacy of metformin in maintaining euglycemia in patients with Gestational Diabetes Mellitus. RMJ, 42 (3), 299-301.



Turabian Style

Amir, Zain el, Zainab Saifuddin, Shumaila Tanveer, and Shazia Amir Khan. 2017. Efficacy of metformin in maintaining euglycemia in patients with Gestational Diabetes Mellitus. Rawal Medical Journal, 42 (3), 299-301.



Chicago Style

Amir, Zain el, Zainab Saifuddin, Shumaila Tanveer, and Shazia Amir Khan. "Efficacy of metformin in maintaining euglycemia in patients with Gestational Diabetes Mellitus." Rawal Medical Journal 42 (2017), 299-301.



MLA (The Modern Language Association) Style

Amir, Zain el, Zainab Saifuddin, Shumaila Tanveer, and Shazia Amir Khan. "Efficacy of metformin in maintaining euglycemia in patients with Gestational Diabetes Mellitus." Rawal Medical Journal 42.3 (2017), 299-301. Print.



APA (American Psychological Association) Style

Amir, Z. e., Saifuddin, Z., Tanveer, S. & Khan, S. A. (2017) Efficacy of metformin in maintaining euglycemia in patients with Gestational Diabetes Mellitus. Rawal Medical Journal, 42 (3), 299-301.




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