ISSN 0303-5212
 

Original Research 
RMJ. 2012; 37(4): 387-389


Serum lipid profile as an indicator of the severity of liver damage in cirrhotic patients.

Fazle Subhan, Imran Khan, Rizwana Arif, Abidullah Khan, Adnan Khan.

Abstract
Background and Aims: Lipid abnormalities are commonly observed in cirrhosis liver. This study was conducted to determine lipid profile in cirrhotic patients and to assess its relationship with the severity of the disease.
Materials and Methods: In an analytical cross-sectional study, we studied 204 patients with cirrhosis (case) and 50 age- and sex-matched healthy normolipidemic patients (comparison) .A questionnaire containing personal characteristics, etiology of cirrhosis, pathologic criteria of Child Pugh and MELD (model for end–stage liver disease) and lipid profile (low density lipoprotein and high density lipoprotein, total cholesterol and triglyceride) was completed for every patient.
Results: There was a significant decrease in serum triglyceride, total, LDL and HDL cholesterol levels in patients with cirrhosis compared to the comparison group (mean of 84.2vs. 189.8, 140.9vs. 186.6, 82.5vs. 139.2, and 38.7vs. 42.5 mg/dL, respectively; all p<0.05). Comparison of lipid profile with pathologic progression of cirrhosis revealed that apart from serum triglyceride level, serum lipid levels diminish linearly with progression of liver damage.
Conclusions: Serum total, LDL and HDL cholesterol level in patients with cirrhosis is inversely correlated with severity of cirrhosis.
Keywords: Lipid profile Cirrhosis, MELD score, Child Pugh Score

Key words: Lipid profile cirrhosis, MELD score, Child Pugh Score


 
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How to Cite this Article
Pubmed Style

Fazle Subhan, Imran Khan, Rizwana Arif, Abidullah Khan, Adnan Khan. Serum lipid profile as an indicator of the severity of liver damage in cirrhotic patients.. RMJ. 2012; 37(4): 387-389.


Web Style

Fazle Subhan, Imran Khan, Rizwana Arif, Abidullah Khan, Adnan Khan. Serum lipid profile as an indicator of the severity of liver damage in cirrhotic patients.. https://www.rmj.org.pk/?mno=20506 [Access: December 08, 2023].


AMA (American Medical Association) Style

Fazle Subhan, Imran Khan, Rizwana Arif, Abidullah Khan, Adnan Khan. Serum lipid profile as an indicator of the severity of liver damage in cirrhotic patients.. RMJ. 2012; 37(4): 387-389.



Vancouver/ICMJE Style

Fazle Subhan, Imran Khan, Rizwana Arif, Abidullah Khan, Adnan Khan. Serum lipid profile as an indicator of the severity of liver damage in cirrhotic patients.. RMJ. (2012), [cited December 08, 2023]; 37(4): 387-389.



Harvard Style

Fazle Subhan, Imran Khan, Rizwana Arif, Abidullah Khan, Adnan Khan (2012) Serum lipid profile as an indicator of the severity of liver damage in cirrhotic patients.. RMJ, 37 (4), 387-389.



Turabian Style

Fazle Subhan, Imran Khan, Rizwana Arif, Abidullah Khan, Adnan Khan. 2012. Serum lipid profile as an indicator of the severity of liver damage in cirrhotic patients.. Rawal Medical Journal, 37 (4), 387-389.



Chicago Style

Fazle Subhan, Imran Khan, Rizwana Arif, Abidullah Khan, Adnan Khan. "Serum lipid profile as an indicator of the severity of liver damage in cirrhotic patients.." Rawal Medical Journal 37 (2012), 387-389.



MLA (The Modern Language Association) Style

Fazle Subhan, Imran Khan, Rizwana Arif, Abidullah Khan, Adnan Khan. "Serum lipid profile as an indicator of the severity of liver damage in cirrhotic patients.." Rawal Medical Journal 37.4 (2012), 387-389. Print.



APA (American Psychological Association) Style

Fazle Subhan, Imran Khan, Rizwana Arif, Abidullah Khan, Adnan Khan (2012) Serum lipid profile as an indicator of the severity of liver damage in cirrhotic patients.. Rawal Medical Journal, 37 (4), 387-389.