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Original Research 
RMJ. 2020; 45(4): 985-989


Red fruit (Pandanus conoideus) inhibits the development of endometriosis lesions through downregulation of NF-kB and VEGF expression

Hardyan Sauqi, Budi Santoso, Widjiati Widjiati, Hendy Hendarto.

Abstract
Objective: To investigate the benefits of P. conoideus fruit extract on inflammation and angiogenesis modulation on the endometrium of endometriosis animal model.
Methodology: Forty female mice (Mus musculus) were divided into two groups (20 in each group). The first group was the endometriosis group. The second group was endometriosis treated with P. conoideus fruit extract. Analysis of NF-B and VEGF expression was carried out by immunohistochemistry. The analysis of endometriosis lesions was performed histologically.
Results: The expression of NF-B, VEGF, and area of the endometriosis lesion was significantly reduced due to the administration of P. conoideus fruit extract.
Conclusion: P.conoideus fruit extract could inhibit angiogenesis and growth of endometriosis lesions through the down regulation of NF-kB activity. This part of the plant can be an alternative herb to inhibit endometriosis progression.

Key words: Endometriosis, peritoneal lesion, inflammation.


 
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How to Cite this Article
Pubmed Style

Sauqi H, Santoso B, Widjiati W, Hendarto H. Red fruit (Pandanus conoideus) inhibits the development of endometriosis lesions through downregulation of NF-kB and VEGF expression. RMJ. 2020; 45(4): 985-989.

Web Style

Sauqi H, Santoso B, Widjiati W, Hendarto H. Red fruit (Pandanus conoideus) inhibits the development of endometriosis lesions through downregulation of NF-kB and VEGF expression. http://www.rmj.org.pk/?mno=93053 [Access: December 18, 2020].

AMA (American Medical Association) Style

Sauqi H, Santoso B, Widjiati W, Hendarto H. Red fruit (Pandanus conoideus) inhibits the development of endometriosis lesions through downregulation of NF-kB and VEGF expression. RMJ. 2020; 45(4): 985-989.


Vancouver/ICMJE Style

Sauqi H, Santoso B, Widjiati W, Hendarto H. Red fruit (Pandanus conoideus) inhibits the development of endometriosis lesions through downregulation of NF-kB and VEGF expression. RMJ. (2020), [cited December 18, 2020]; 45(4): 985-989.


Harvard Style

Sauqi, H., Santoso, . B., Widjiati, . W. & Hendarto, . H. (2020) Red fruit (Pandanus conoideus) inhibits the development of endometriosis lesions through downregulation of NF-kB and VEGF expression. RMJ, 45 (4), 985-989.


Turabian Style

Sauqi, Hardyan, Budi Santoso, Widjiati Widjiati, and Hendy Hendarto. 2020. Red fruit (Pandanus conoideus) inhibits the development of endometriosis lesions through downregulation of NF-kB and VEGF expression. Rawal Medical Journal, 45 (4), 985-989.


Chicago Style

Sauqi, Hardyan, Budi Santoso, Widjiati Widjiati, and Hendy Hendarto. "Red fruit (Pandanus conoideus) inhibits the development of endometriosis lesions through downregulation of NF-kB and VEGF expression." Rawal Medical Journal 45 (2020), 985-989.


MLA (The Modern Language Association) Style

Sauqi, Hardyan, Budi Santoso, Widjiati Widjiati, and Hendy Hendarto. "Red fruit (Pandanus conoideus) inhibits the development of endometriosis lesions through downregulation of NF-kB and VEGF expression." Rawal Medical Journal 45.4 (2020), 985-989. Print.


APA (American Psychological Association) Style

Sauqi, H., Santoso, . B., Widjiati, . W. & Hendarto, . H. (2020) Red fruit (Pandanus conoideus) inhibits the development of endometriosis lesions through downregulation of NF-kB and VEGF expression. Rawal Medical Journal, 45 (4), 985-989.







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