Open Access and Peer-reviewed
Home Journal Issues Guide for Authors Editorial Board Aims & Scope About Journal News & Announcements


Original Research 
RMJ. 2020; 45(3): 513-518


HOMA-IR and TyG Index as acute phase reactants in obese and lean subjects

Tahrir Etihad Kadium, Abdulhadi Alrubaie, Ahmed Abed Marzook.

Abstract
Objective: To evaluate biomarkers of insulin resistance and acute phase reactants in obese, overweight and lean subjects and investigate the associations among those biomarkers.
Methodology: This cross sectional study included 158 subjects who were stratified into three groups. Group1 comprised 53 obese patients (BMI≥ 30 kg/m2); group 2 were 54 overweight subjects, and group 3 had 51 healthy lean (BMI <25 kg/m2). Insulin resistance biomarker was assessed by Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) and Triglyceride to Glucose (TyG) index. High-sensitivity C-reactive protein (hsCRP), ceruloplasmin (CP), haptoglobin (HP) and albumin were also evaluated as acute phase reactants (APRs).
Results: HOMA-IR and TyG index, hs-CRP, CP, HP and BMI were significantly increased in both group1 and 2 as compared to lean Subjects (p<0.01). Albumin levels were lower in group1versus group 2 and group 3, respectively (p>0.05). The TyG index and HOMA-IR showed significant positive correlations with waist circumference (WC), waist to hip ratio (WHR), BMI, HP, CP, (p<0.001), and negative correlation with albumin (p<0.01). Multiple regression analysis showed that hsCRP and CP were the most powerful predictors of insulin resistance in obese and overweight subject as compared to other APRs in this study. Additionally, WHR and BMI are strong independent risk factors for insulin resistance in these subjects.
Conclusion: Insulin resistance biomarkers HOMA-IR and TyG index were linked with acute phase reactants and obesity indices.

Key words: Obesity, insulin resistance, inflammation, acute phase reactants.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Tahrir Etihad Kadium
Articles by Abdulhadi Alrubaie
Articles by Ahmed Abed Marzook
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Kadium TE, Alrubaie A, Marzook AA. HOMA-IR and TyG Index as acute phase reactants in obese and lean subjects. RMJ. 2020; 45(3): 513-518.


Web Style

Kadium TE, Alrubaie A, Marzook AA. HOMA-IR and TyG Index as acute phase reactants in obese and lean subjects. http://www.rmj.org.pk/?mno=86225 [Access: September 02, 2020].


AMA (American Medical Association) Style

Kadium TE, Alrubaie A, Marzook AA. HOMA-IR and TyG Index as acute phase reactants in obese and lean subjects. RMJ. 2020; 45(3): 513-518.



Vancouver/ICMJE Style

Kadium TE, Alrubaie A, Marzook AA. HOMA-IR and TyG Index as acute phase reactants in obese and lean subjects. RMJ. (2020), [cited September 02, 2020]; 45(3): 513-518.



Harvard Style

Kadium, T. E., Alrubaie, . A. & Marzook, . A. A. (2020) HOMA-IR and TyG Index as acute phase reactants in obese and lean subjects. RMJ, 45 (3), 513-518.



Turabian Style

Kadium, Tahrir Etihad, Abdulhadi Alrubaie, and Ahmed Abed Marzook. 2020. HOMA-IR and TyG Index as acute phase reactants in obese and lean subjects. Rawal Medical Journal, 45 (3), 513-518.



Chicago Style

Kadium, Tahrir Etihad, Abdulhadi Alrubaie, and Ahmed Abed Marzook. "HOMA-IR and TyG Index as acute phase reactants in obese and lean subjects." Rawal Medical Journal 45 (2020), 513-518.



MLA (The Modern Language Association) Style

Kadium, Tahrir Etihad, Abdulhadi Alrubaie, and Ahmed Abed Marzook. "HOMA-IR and TyG Index as acute phase reactants in obese and lean subjects." Rawal Medical Journal 45.3 (2020), 513-518. Print.



APA (American Psychological Association) Style

Kadium, T. E., Alrubaie, . A. & Marzook, . A. A. (2020) HOMA-IR and TyG Index as acute phase reactants in obese and lean subjects. Rawal Medical Journal, 45 (3), 513-518.








AUTHOR LOGIN

REVIEWER LOGIN

Indexed
&
Abstracted


Indexed in WHO Index Medicus IMEMR, Emromedex, Pakmedinet, ExtraMED,  Scopus and Web of Science

                     Approved by the Higher Education Commission of Pakistan 


ABOUT JOURNAL
POLICIES
STATEMENTS

This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author. This is in accordance with the Budapest Open Access Initiative (BOAI) definition of open access.

The articles in Rawal Medical Journal are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.