ISSN 0303-5212
 

Original Research 
RMJ. 2020; 45(3): 513-518


HOMA-IR and TyG Index as acute phase reactants in obese and lean subjects

Tahrir Etihad Kadium, Abdulhadi Alrubaie, Ahmed Abed Marzook.

Abstract
Objective: To evaluate biomarkers of insulin resistance and acute phase reactants in obese, overweight and lean subjects and investigate the associations among those biomarkers.
Methodology: This cross sectional study included 158 subjects who were stratified into three groups. Group1 comprised 53 obese patients (BMI≥ 30 kg/m2); group 2 were 54 overweight subjects, and group 3 had 51 healthy lean (BMI <25 kg/m2). Insulin resistance biomarker was assessed by Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) and Triglyceride to Glucose (TyG) index. High-sensitivity C-reactive protein (hsCRP), ceruloplasmin (CP), haptoglobin (HP) and albumin were also evaluated as acute phase reactants (APRs).
Results: HOMA-IR and TyG index, hs-CRP, CP, HP and BMI were significantly increased in both group1 and 2 as compared to lean Subjects (p<0.01). Albumin levels were lower in group1versus group 2 and group 3, respectively (p>0.05). The TyG index and HOMA-IR showed significant positive correlations with waist circumference (WC), waist to hip ratio (WHR), BMI, HP, CP, (p<0.001), and negative correlation with albumin (p<0.01). Multiple regression analysis showed that hsCRP and CP were the most powerful predictors of insulin resistance in obese and overweight subject as compared to other APRs in this study. Additionally, WHR and BMI are strong independent risk factors for insulin resistance in these subjects.
Conclusion: Insulin resistance biomarkers HOMA-IR and TyG index were linked with acute phase reactants and obesity indices.

Key words: Obesity, insulin resistance, inflammation, acute phase reactants.


 
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How to Cite this Article
Pubmed Style

Kadium TE, Alrubaie A, Marzook AA. HOMA-IR and TyG Index as acute phase reactants in obese and lean subjects. RMJ. 2020; 45(3): 513-518.


Web Style

Kadium TE, Alrubaie A, Marzook AA. HOMA-IR and TyG Index as acute phase reactants in obese and lean subjects. https://www.rmj.org.pk/?mno=86225 [Access: December 04, 2023].


AMA (American Medical Association) Style

Kadium TE, Alrubaie A, Marzook AA. HOMA-IR and TyG Index as acute phase reactants in obese and lean subjects. RMJ. 2020; 45(3): 513-518.



Vancouver/ICMJE Style

Kadium TE, Alrubaie A, Marzook AA. HOMA-IR and TyG Index as acute phase reactants in obese and lean subjects. RMJ. (2020), [cited December 04, 2023]; 45(3): 513-518.



Harvard Style

Kadium, T. E., Alrubaie, . A. & Marzook, . A. A. (2020) HOMA-IR and TyG Index as acute phase reactants in obese and lean subjects. RMJ, 45 (3), 513-518.



Turabian Style

Kadium, Tahrir Etihad, Abdulhadi Alrubaie, and Ahmed Abed Marzook. 2020. HOMA-IR and TyG Index as acute phase reactants in obese and lean subjects. Rawal Medical Journal, 45 (3), 513-518.



Chicago Style

Kadium, Tahrir Etihad, Abdulhadi Alrubaie, and Ahmed Abed Marzook. "HOMA-IR and TyG Index as acute phase reactants in obese and lean subjects." Rawal Medical Journal 45 (2020), 513-518.



MLA (The Modern Language Association) Style

Kadium, Tahrir Etihad, Abdulhadi Alrubaie, and Ahmed Abed Marzook. "HOMA-IR and TyG Index as acute phase reactants in obese and lean subjects." Rawal Medical Journal 45.3 (2020), 513-518. Print.



APA (American Psychological Association) Style

Kadium, T. E., Alrubaie, . A. & Marzook, . A. A. (2020) HOMA-IR and TyG Index as acute phase reactants in obese and lean subjects. Rawal Medical Journal, 45 (3), 513-518.