Open Access and Peer-reviewed
Home Journal Issues Guide for Authors Editorial Board Aims & Scope About Journal News & Announcements


Original Research 
RMJ. 2020; 45(2): 342-346


Association of Cyclin D progression with malignant transformation of oral mucosa in tobacco users

Sarwat Batool, Syed Naqeeb Ali, Najia Soomro, Syed Liaquat Ali.

Abstract
Objectives: To assess the expression of Cyclin D in transition of normal oral mucosa to oral squamous cell carcinoma (OSCC) and to find the possible association of immunostaining in various clinicopathological and histopathological distribution of OSCC.
Methodology: In this cross sectional analytical study, 120 diagnosed paraffin embedded blocks were included comprising of 60 samples of normal oral mucosa (Group 1) and 60 cases of various grades of OSCC (Group 2). All tissue samples belonged to tobacco chewers. Patientsí record files were studied for age, gender, tobacco habits and various clinicopathological details. Immunohistochemistry was performed using Cyclin D monoclonal antibodies on all samples. Staining with Cyclin D was done to find its possible association with various clinicopathological and histopathological variables. Association of Cyclin D expression was also observed in transition of normal mucosa to OSCC.
Results: In Group 1, 75% were negative for Cyclin D. In Group 2, 100% were positive for Cyclin D. We found significant association for Cyclin D staining in transition of normal oral mucosa to OSCC in tobacco users. Nonsignificant association was found in Cyclin D positivity in various grades and stages of OSCC.
Conclusion: The overall Cyclin D expression was shown not to be increased with increasing grades and stages of OSCC in tobacco users. Positive association was seen in Cyclin D immunopositivity with transition of healthy mucosa to OSCC among tobacco users.

Key words: Cyclin D, Normal oral mucosa, Oral squamous cell carcinoma. Correction done : KEY WORDS: Cyclin D, Normal oral mucosa, Oral squamous cell carcinoma. Immunohistochemistry


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Sarwat Batool
Articles by Syed Naqeeb Ali
Articles by Najia Soomro
Articles by Syed Liaquat Ali
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Batool S, Ali SN, Soomro N, Ali SL. Association of Cyclin D progression with malignant transformation of oral mucosa in tobacco users. RMJ. 2020; 45(2): 342-346.


Web Style

Batool S, Ali SN, Soomro N, Ali SL. Association of Cyclin D progression with malignant transformation of oral mucosa in tobacco users. http://www.rmj.org.pk/?mno=76912 [Access: May 10, 2020].


AMA (American Medical Association) Style

Batool S, Ali SN, Soomro N, Ali SL. Association of Cyclin D progression with malignant transformation of oral mucosa in tobacco users. RMJ. 2020; 45(2): 342-346.



Vancouver/ICMJE Style

Batool S, Ali SN, Soomro N, Ali SL. Association of Cyclin D progression with malignant transformation of oral mucosa in tobacco users. RMJ. (2020), [cited May 10, 2020]; 45(2): 342-346.



Harvard Style

Batool, S., Ali, . S. N., Soomro, . N. & Ali, . S. L. (2020) Association of Cyclin D progression with malignant transformation of oral mucosa in tobacco users. RMJ, 45 (2), 342-346.



Turabian Style

Batool, Sarwat, Syed Naqeeb Ali, Najia Soomro, and Syed Liaquat Ali. 2020. Association of Cyclin D progression with malignant transformation of oral mucosa in tobacco users. Rawal Medical Journal, 45 (2), 342-346.



Chicago Style

Batool, Sarwat, Syed Naqeeb Ali, Najia Soomro, and Syed Liaquat Ali. "Association of Cyclin D progression with malignant transformation of oral mucosa in tobacco users." Rawal Medical Journal 45 (2020), 342-346.



MLA (The Modern Language Association) Style

Batool, Sarwat, Syed Naqeeb Ali, Najia Soomro, and Syed Liaquat Ali. "Association of Cyclin D progression with malignant transformation of oral mucosa in tobacco users." Rawal Medical Journal 45.2 (2020), 342-346. Print.



APA (American Psychological Association) Style

Batool, S., Ali, . S. N., Soomro, . N. & Ali, . S. L. (2020) Association of Cyclin D progression with malignant transformation of oral mucosa in tobacco users. Rawal Medical Journal, 45 (2), 342-346.








AUTHOR LOGIN

REVIEWER LOGIN

Indexed
&
Abstracted


Indexed in WHO Index Medicus IMEMR, Emromedex, Pakmedinet, ExtraMED and Scopus, Web of Science

  Approved by the Higher Education Commission of Pakistan and Pakistan Medical and Dental Council


ABOUT JOURNAL
POLICIES
STATEMENTS

This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author. This is in accordance with the Budapest Open Access Initiative (BOAI) definition of open access.

The articles in Rawal Medical Journal are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.