ISSN 0303-5212
 

Original Research 


Schistosoma mansoni: The prophylactic and curative effects of propolis in experimentally infected mice

Ragaa M. Issa.

Abstract
Objective: To evaluate the effect of propolis, a natural bee product on
lung and liver schistosomules as well on adult worms of Schistosoma
mansoni in immunosuppressed mice.
Meterials and Methods: All groups were infected with 100±10 S.
mansoni cercariae/mouse injected subcutaneously. Immunosuppression
was induced by hydrocortisone hemisuccinate at a dose of 25 mg/kg b.w.
intramusculary twice weekly for 8 weeks, starting 10 days before
infection. Propolis was administered orally at a dose of 250 mg/kg/day,
starting 5 days before infection and continued up to 45 days postinfection,
to cover all stages of S. mansoni infection. Praziquantel (PZQ)
was administered orally at a dose of 500 mg/kg/day, on the 5th and 6th
and 45th and 46th days post-infection.
Results: The number of lung schistosomules showed a significant
reduction of 59.22% with propolis and 98.89% with PZQ. The
administration of propolis caused a marked reduction of egg counts in
stool (61.8%) and tissues (49.9% and 45.8%). Propolis produced a
significant reduction of 58.38% in adult worms. PZQ produced a
reduction of 83.65% in adult worms and 98.38% in stool egg counts and
(91.99% and 89.22% ) reductions in liver and intestine egg counts
respectively.
Conclusions: The effect of propolis when compared to PZQ is promising
in immunosuppressed S. mansoni infected mice. (Rawal Med J
2007;32:94-98)

Key words: Schistosomiasis, propolis, praziquantil


 
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Pubmed Style

Ragaa M. Issa. Schistosoma mansoni: The prophylactic and curative effects of propolis in experimentally infected mice. RMJ. 2007; 32(2): 94-98.


Web Style

Ragaa M. Issa. Schistosoma mansoni: The prophylactic and curative effects of propolis in experimentally infected mice. https://www.rmj.org.pk/?mno=7580 [Access: December 07, 2023].


AMA (American Medical Association) Style

Ragaa M. Issa. Schistosoma mansoni: The prophylactic and curative effects of propolis in experimentally infected mice. RMJ. 2007; 32(2): 94-98.



Vancouver/ICMJE Style

Ragaa M. Issa. Schistosoma mansoni: The prophylactic and curative effects of propolis in experimentally infected mice. RMJ. (2007), [cited December 07, 2023]; 32(2): 94-98.



Harvard Style

Ragaa M. Issa (2007) Schistosoma mansoni: The prophylactic and curative effects of propolis in experimentally infected mice. RMJ, 32 (2), 94-98.



Turabian Style

Ragaa M. Issa. 2007. Schistosoma mansoni: The prophylactic and curative effects of propolis in experimentally infected mice. Rawal Medical Journal, 32 (2), 94-98.



Chicago Style

Ragaa M. Issa. "Schistosoma mansoni: The prophylactic and curative effects of propolis in experimentally infected mice." Rawal Medical Journal 32 (2007), 94-98.



MLA (The Modern Language Association) Style

Ragaa M. Issa. "Schistosoma mansoni: The prophylactic and curative effects of propolis in experimentally infected mice." Rawal Medical Journal 32.2 (2007), 94-98. Print.



APA (American Psychological Association) Style

Ragaa M. Issa (2007) Schistosoma mansoni: The prophylactic and curative effects of propolis in experimentally infected mice. Rawal Medical Journal, 32 (2), 94-98.