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Effects of captopril and amlodipine on serum uric acid in type 2 diabetic hypertensive patients.

Isam Hamo Mahmood.

Abstract
Objective: To investigate the effects of two well known antihypertensive drugs
captopril and amlodipine on serum uric acid level in type 2 diabetic hypertensive
patients.
Methods: One hundred hypertensive type 2 diabetic patients were divided into two
groups, with 50 patients in each group. Group 1 was given captopril and group 2
amlodipine. A control group was included. Blood pressure and uric acid level were
measured before and after drug administration.
Results: A significantly higher levels of uric acid were found in the diabetic
hypertensive patients as compared with control group. A significant drop of uric acid
was noted after treatment with both captopril and amlodipine. Reduction of uric acid
after therapy with captopril (49.930.34) and amlodipine (31.430.1) showed
significant difference (P<0.005).
Conclusions: This study demonstrates significantly higher serum uric acid
concentrations in type 2 diabetic hypertensive patients. Both captopril and amlodipine
therapy produced a fall in serum uric acid level. They can be useful therapeutic agents
to control blood pressure and to reduce serum uric acid level in type 2 diabetic
hypertensive patients with hyperuricaemia. (Rawal Med J 2008;33:50-53).

Key words: Hyperuricemia, diabetes, hypertension, captopril, amlodipine.


 
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Pubmed Style

Isam Hamo Mahmood. Effects of captopril and amlodipine on serum uric acid in type 2 diabetic hypertensive patients.. RMJ. 2008; 33(1): 52-55.


Web Style

Isam Hamo Mahmood. Effects of captopril and amlodipine on serum uric acid in type 2 diabetic hypertensive patients.. http://www.rmj.org.pk/?mno=7541 [Access: October 16, 2019].


AMA (American Medical Association) Style

Isam Hamo Mahmood. Effects of captopril and amlodipine on serum uric acid in type 2 diabetic hypertensive patients.. RMJ. 2008; 33(1): 52-55.



Vancouver/ICMJE Style

Isam Hamo Mahmood. Effects of captopril and amlodipine on serum uric acid in type 2 diabetic hypertensive patients.. RMJ. (2008), [cited October 16, 2019]; 33(1): 52-55.



Harvard Style

Isam Hamo Mahmood (2008) Effects of captopril and amlodipine on serum uric acid in type 2 diabetic hypertensive patients.. RMJ, 33 (1), 52-55.



Turabian Style

Isam Hamo Mahmood. 2008. Effects of captopril and amlodipine on serum uric acid in type 2 diabetic hypertensive patients.. Rawal Medical Journal, 33 (1), 52-55.



Chicago Style

Isam Hamo Mahmood. "Effects of captopril and amlodipine on serum uric acid in type 2 diabetic hypertensive patients.." Rawal Medical Journal 33 (2008), 52-55.



MLA (The Modern Language Association) Style

Isam Hamo Mahmood. "Effects of captopril and amlodipine on serum uric acid in type 2 diabetic hypertensive patients.." Rawal Medical Journal 33.1 (2008), 52-55. Print.



APA (American Psychological Association) Style

Isam Hamo Mahmood (2008) Effects of captopril and amlodipine on serum uric acid in type 2 diabetic hypertensive patients.. Rawal Medical Journal, 33 (1), 52-55.








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