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Original Research 
RMJ. 2020; 45(1): 154-157


Comparison of serum neutrophil gelatinase associated lipocalin (NGAL) levels in pre-eclamptic and normotensive pregnant women.

Shazmah Ahmad, Sumbla Ghaznavi, Nadia Rasheed, Muhammad Ikram Ullah.

Abstract
Objective: To compare the serum neutrophil gelatinase associated lipocalin (NGAL) levels between pre-eclamptic (PE) and healthy pregnant women.
Methodology: Twenty-two pre-eclamptic and 20 normotensive pregnant women were enrolled in the study after taking written informed consent. Demographic data was recorded. Biochemical parameters like serum uric acid and serum creatinine levels were noted from patient record. Blood pressure (BP) was measured by a standard sphygmomanometer and spot urine sample was collected to detect urine protein by dipstick method. Blood samples were collected and serum levels of NGAL were determined by ELISA. Data analysis was carried out by using SPSS version 20.0.
Result: Out of 22 pre-eclampsia women, 64% had late pre-eclampsia and remaining presented with early disease. The degree of disease was severe in 55% patients and other presented with milder form of pre-eclampsia. The mean serum NGAL was 135.13113.94 ng/ml in PE group and 132.1053.36 ng/ml in control group (p=0.290). Serum uric acid and creatinine were high in PE group, indicating kidney injury in pre-eclamptic subjects.
Conclusion: Serum NGAL levels were not associated with pre-eclampsia disease although higher NGAL levels were found in patients which may indicates some inflammatory processes. Further studies on larger scale should be conducted to confirm the clinical findings for an increase of NGAL levels.

Key words: Pregnancy, Pre-eclampsia, Serum NGAL.


 
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How to Cite this Article
Pubmed Style

Ahmad S, Ghaznavi S, Rasheed N, Ullah MI. Comparison of serum neutrophil gelatinase associated lipocalin (NGAL) levels in pre-eclamptic and normotensive pregnant women.. RMJ. 2020; 45(1): 154-157.


Web Style

Ahmad S, Ghaznavi S, Rasheed N, Ullah MI. Comparison of serum neutrophil gelatinase associated lipocalin (NGAL) levels in pre-eclamptic and normotensive pregnant women.. http://www.rmj.org.pk/?mno=72317 [Access: March 29, 2020].


AMA (American Medical Association) Style

Ahmad S, Ghaznavi S, Rasheed N, Ullah MI. Comparison of serum neutrophil gelatinase associated lipocalin (NGAL) levels in pre-eclamptic and normotensive pregnant women.. RMJ. 2020; 45(1): 154-157.



Vancouver/ICMJE Style

Ahmad S, Ghaznavi S, Rasheed N, Ullah MI. Comparison of serum neutrophil gelatinase associated lipocalin (NGAL) levels in pre-eclamptic and normotensive pregnant women.. RMJ. (2020), [cited March 29, 2020]; 45(1): 154-157.



Harvard Style

Ahmad, S., Ghaznavi, . S., Rasheed, . N. & Ullah, . M. I. (2020) Comparison of serum neutrophil gelatinase associated lipocalin (NGAL) levels in pre-eclamptic and normotensive pregnant women.. RMJ, 45 (1), 154-157.



Turabian Style

Ahmad, Shazmah, Sumbla Ghaznavi, Nadia Rasheed, and Muhammad Ikram Ullah. 2020. Comparison of serum neutrophil gelatinase associated lipocalin (NGAL) levels in pre-eclamptic and normotensive pregnant women.. Rawal Medical Journal, 45 (1), 154-157.



Chicago Style

Ahmad, Shazmah, Sumbla Ghaznavi, Nadia Rasheed, and Muhammad Ikram Ullah. "Comparison of serum neutrophil gelatinase associated lipocalin (NGAL) levels in pre-eclamptic and normotensive pregnant women.." Rawal Medical Journal 45 (2020), 154-157.



MLA (The Modern Language Association) Style

Ahmad, Shazmah, Sumbla Ghaznavi, Nadia Rasheed, and Muhammad Ikram Ullah. "Comparison of serum neutrophil gelatinase associated lipocalin (NGAL) levels in pre-eclamptic and normotensive pregnant women.." Rawal Medical Journal 45.1 (2020), 154-157. Print.



APA (American Psychological Association) Style

Ahmad, S., Ghaznavi, . S., Rasheed, . N. & Ullah, . M. I. (2020) Comparison of serum neutrophil gelatinase associated lipocalin (NGAL) levels in pre-eclamptic and normotensive pregnant women.. Rawal Medical Journal, 45 (1), 154-157.








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