ISSN 0303-5212
 

Original Research 


Prevalence and Antimicrobial Susceptibility of Extended-spectrum β- Lactamase- producing klebsiella pneumoniae at a Microbiology Diagnostic Center in Kashmir

Shamweel Ahmad.

Abstract
Objectives: To determine the prevalence and antimicrobial susceptibility of extendedspectrum
β- lactamase (ESBL) producing Klebsiella pneumoniae isolated from different
clinical specimens.
Methods: A total of 144 (10.2%) isolates of Klebsiella pneumoniae were recovered from
1409 different clinical specimens like urines, wound swabs, sputum and blood at Al-Haram
Diagnostic, Research and Training Center, Kashmir, India over a period of 24 months from
December, 2005 to November, 2007. All these isolates were tested for ESBL production.
Results: Of 144 isolates of K. pneumoniae, 18 (12.5%) were positive for ESBL production.
Most ESBL producers (50%) were from urines, followed by infected wounds (22.2%),
sputum (16.7%) and blood (11.1%). ESBL producing strains of K. pneumoniae showed the
highest susceptibility to imipenem (~89%). The non β- lactam antibiotics with greatest
activity against these ESBL strains were ciprofloxacin (72%), Amikacin (66%), tobramycin
(61 %) and gentamicin (50%).
1
Conclusion: Our findings demonstrate a high percentage of ESBL producers among clinical
isolates of K. pneumoniae and a high rate of multidrug resistance. Two (11.1%) of strains of
ESBL producing K. pneumoniae were resistant to imipenem. Therefore, regular monitoring
of imipenem sensitivity and routine testing of newer carbapenems like meropenem and
ertapenem should be carried out further. (Rawal Med J 2009;34:68-72).

Key words: K. pneumoniae, ESBLs, Multidrug resistance.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Shamweel Ahmad
on Google
on Google Scholar

How to Cite this Article
Pubmed Style

Shamweel Ahmad. Prevalence and Antimicrobial Susceptibility of Extended-spectrum β- Lactamase- producing klebsiella pneumoniae at a Microbiology Diagnostic Center in Kashmir. RMJ. 2009; 34(1): 68-71.


Web Style

Shamweel Ahmad. Prevalence and Antimicrobial Susceptibility of Extended-spectrum β- Lactamase- producing klebsiella pneumoniae at a Microbiology Diagnostic Center in Kashmir. https://www.rmj.org.pk/?mno=7221 [Access: December 06, 2023].


AMA (American Medical Association) Style

Shamweel Ahmad. Prevalence and Antimicrobial Susceptibility of Extended-spectrum β- Lactamase- producing klebsiella pneumoniae at a Microbiology Diagnostic Center in Kashmir. RMJ. 2009; 34(1): 68-71.



Vancouver/ICMJE Style

Shamweel Ahmad. Prevalence and Antimicrobial Susceptibility of Extended-spectrum β- Lactamase- producing klebsiella pneumoniae at a Microbiology Diagnostic Center in Kashmir. RMJ. (2009), [cited December 06, 2023]; 34(1): 68-71.



Harvard Style

Shamweel Ahmad (2009) Prevalence and Antimicrobial Susceptibility of Extended-spectrum β- Lactamase- producing klebsiella pneumoniae at a Microbiology Diagnostic Center in Kashmir. RMJ, 34 (1), 68-71.



Turabian Style

Shamweel Ahmad. 2009. Prevalence and Antimicrobial Susceptibility of Extended-spectrum β- Lactamase- producing klebsiella pneumoniae at a Microbiology Diagnostic Center in Kashmir. Rawal Medical Journal, 34 (1), 68-71.



Chicago Style

Shamweel Ahmad. "Prevalence and Antimicrobial Susceptibility of Extended-spectrum β- Lactamase- producing klebsiella pneumoniae at a Microbiology Diagnostic Center in Kashmir." Rawal Medical Journal 34 (2009), 68-71.



MLA (The Modern Language Association) Style

Shamweel Ahmad. "Prevalence and Antimicrobial Susceptibility of Extended-spectrum β- Lactamase- producing klebsiella pneumoniae at a Microbiology Diagnostic Center in Kashmir." Rawal Medical Journal 34.1 (2009), 68-71. Print.



APA (American Psychological Association) Style

Shamweel Ahmad (2009) Prevalence and Antimicrobial Susceptibility of Extended-spectrum β- Lactamase- producing klebsiella pneumoniae at a Microbiology Diagnostic Center in Kashmir. Rawal Medical Journal, 34 (1), 68-71.