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Original Research 
RMJ. 2020; 45(4): 771-774


Association of serum sphingosine-1-phosphate with forced expiratory volume and absolute eosinophil count in asthma patients

Haji Muhammad Rashid, Mudassar Khan, Muhammad Jamal, Nadia Awan, Muhammad Waseem.

Abstract
Objective: To investigate the association of serum sphingosine-1-phosphate with forced expiratory volume and absolute eosinophil count in asthmatic patients.
Methodology: In this cross sectional comparative study, 36 Asthmatic patients and 36 non-asthmatic healthy adults as control were selected through convenient sampling. Forced Expiratory Volume (FEV1), Absolute Eosinophil Count (AEC) and serum Sphingosine-1-phosphate (S1P) of all patients and control were measured.
Results: Mean FEV1 value of asthmatics (49.3014.79) was significantly lower than mean FEV1 value (92.85.9) of controls, while mean AEC (0.230.1) and S1P (1942.74 426.30) were significantly higher in asthmatic patients than mean AEC (0.070.02) and S1P (940.44210.9) of controls (p=0.001). Serum S1P levels in asthmatic patients were negatively associated with FEV1 (r2 = -0.808), while, serum S1P levels were positively associated with AEC (r2 = 0.674) in asthmatic group. Area under the curve in ROC analysis was 0.98, cut off value of S1P with 91.7% sensitivity and 83.1% specificity was 1251 nmol/L for asthma.
Conclusion: Serum S1P levels were negatively associated with the FEV1 and positively associated with ACE.

Key words: Asthma, eosinophil, inflammation, sphingosine-1-phosphate.


 
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How to Cite this Article
Pubmed Style

Rashid HM, Khan M, Jamal M, Awan N, Waseem M. Association of serum sphingosine-1-phosphate with forced expiratory volume and absolute eosinophil count in asthma patients. RMJ. 2020; 45(4): 771-774.


Web Style

Rashid HM, Khan M, Jamal M, Awan N, Waseem M. Association of serum sphingosine-1-phosphate with forced expiratory volume and absolute eosinophil count in asthma patients. http://www.rmj.org.pk/?mno=68347 [Access: December 18, 2020].


AMA (American Medical Association) Style

Rashid HM, Khan M, Jamal M, Awan N, Waseem M. Association of serum sphingosine-1-phosphate with forced expiratory volume and absolute eosinophil count in asthma patients. RMJ. 2020; 45(4): 771-774.



Vancouver/ICMJE Style

Rashid HM, Khan M, Jamal M, Awan N, Waseem M. Association of serum sphingosine-1-phosphate with forced expiratory volume and absolute eosinophil count in asthma patients. RMJ. (2020), [cited December 18, 2020]; 45(4): 771-774.



Harvard Style

Rashid, H. M., Khan, . M., Jamal, . M., Awan, . N. & Waseem, . M. (2020) Association of serum sphingosine-1-phosphate with forced expiratory volume and absolute eosinophil count in asthma patients. RMJ, 45 (4), 771-774.



Turabian Style

Rashid, Haji Muhammad, Mudassar Khan, Muhammad Jamal, Nadia Awan, and Muhammad Waseem. 2020. Association of serum sphingosine-1-phosphate with forced expiratory volume and absolute eosinophil count in asthma patients. Rawal Medical Journal, 45 (4), 771-774.



Chicago Style

Rashid, Haji Muhammad, Mudassar Khan, Muhammad Jamal, Nadia Awan, and Muhammad Waseem. "Association of serum sphingosine-1-phosphate with forced expiratory volume and absolute eosinophil count in asthma patients." Rawal Medical Journal 45 (2020), 771-774.



MLA (The Modern Language Association) Style

Rashid, Haji Muhammad, Mudassar Khan, Muhammad Jamal, Nadia Awan, and Muhammad Waseem. "Association of serum sphingosine-1-phosphate with forced expiratory volume and absolute eosinophil count in asthma patients." Rawal Medical Journal 45.4 (2020), 771-774. Print.



APA (American Psychological Association) Style

Rashid, H. M., Khan, . M., Jamal, . M., Awan, . N. & Waseem, . M. (2020) Association of serum sphingosine-1-phosphate with forced expiratory volume and absolute eosinophil count in asthma patients. Rawal Medical Journal, 45 (4), 771-774.








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