Association of serum sphingosine-1-phosphate with forced expiratory volume and absolute eosinophil count in asthma patients

Haji Muhammad Rashid| Mudassar Khan| Muhammad Jamal| Nadia Awan| Muhammad Waseem

Abstract
Objective: To investigate the association of serum sphingosine-1-phosphate with forced expiratory volume and absolute eosinophil count in asthmatic patients.
Methodology: In this cross sectional comparative study, 36 Asthmatic patients and 36 non-asthmatic healthy adults as control were selected through convenient sampling. Forced Expiratory Volume (FEV1), Absolute Eosinophil Count (AEC) and serum Sphingosine-1-phosphate (S1P) of all patients and control were measured.
Results: Mean FEV1 value of asthmatics (49.30±14.79) was significantly lower than mean FEV1 value (92.8±5.9) of controls, while mean AEC (0.23±0.1) and S1P (1942.74± 426.30) were significantly higher in asthmatic patients than mean AEC (0.07±0.02) and S1P (940.44±210.9) of controls (p=0.001). Serum S1P levels in asthmatic patients were negatively associated with FEV1 (r2 = -0.808), while, serum S1P levels were positively associated with AEC (r2 = 0.674) in asthmatic group. Area under the curve in ROC analysis was 0.98, cut off value of S1P with 91.7% sensitivity and 83.1% specificity was 1251 nmol/L for asthma.
Conclusion: Serum S1P levels were negatively associated with the FEV1 and positively associated with ACE.

Key words: Asthma, eosinophil, inflammation, sphingosine-1-phosphate.

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