ISSN 0303-5212
 

Original Research 


Antibiotic susceptibility pattern in an intensive care unit of a tertiary care hospital in Pakistan

Mir Tahir Hussain Talpur, Kashif Ullah Shabir, Khalil Ullah Shabir, Muhammad Tauqeer Katbar, Uzair Yaqoob, Shahida Kashif.

Abstract
Objective: To determine the most common microorganisms in the body secretions of patients admitted in an intensive care unit (ICU) of a tertiary care hospital and estimate antibiotic sensitivities to those organisms.
Methodology: In this cross-sectional study performed in the medical ICU of Jinnah Postgraduate Medical Center, Karachi, from January to February 2019, 95 specimens were collected from blood, endotracheal secretions, central catheter tips, and urine. Antibiotic sensitivity was tested by the disk diffusion method.
Results: Out of 95 patients, 69.5% were males and mean age was 27.37±10 years. All patients had positive bacterial cultures except one that was of Candida albicans. Bacteria were mostly gram-negative (85.3%, n=81) and the most frequently encountered were Pseudomonas aeruginosa (34.7%). Pseudomonas aeruginosa was most sensitive to polymixin-B (17.8%, n=17). For Acinetobacter baumannii, colistin (10.5%, n=10) followed by cefoperazone/sulbactam (5.2%, n=5); for Klebsiella pneumoniae, amikacin and imipenem had equally highest sensitivity (8.4%, n=8). For Staphylococcus aureus, amikacin sensitivity was found in the majority (7.3%, n=7).
Conclusion: Microorganisms with multidrug-resistance especially gram-negative ones are increasing day by day. A high percentage of resistance to the frequently used antibiotics (cephalosporins, quinolones, and carbapenems) was found. The antibiotics prescribed empirically should be according to regularly updated antibiogram.

Key words: Culture, antibiotics, antibiotic resistance, multidrug resistance, antibiogram, intensive care units.


 
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How to Cite this Article
Pubmed Style

Talpur MTH, Shabir KU, Shabir KU, Katbar MT, Yaqoob U, Kashif S. Antibiotic susceptibility pattern in an intensive care unit of a tertiary care hospital in Pakistan. RMJ. 2020; 45(1): 17-21.


Web Style

Talpur MTH, Shabir KU, Shabir KU, Katbar MT, Yaqoob U, Kashif S. Antibiotic susceptibility pattern in an intensive care unit of a tertiary care hospital in Pakistan. https://www.rmj.org.pk/?mno=65776 [Access: December 10, 2023].


AMA (American Medical Association) Style

Talpur MTH, Shabir KU, Shabir KU, Katbar MT, Yaqoob U, Kashif S. Antibiotic susceptibility pattern in an intensive care unit of a tertiary care hospital in Pakistan. RMJ. 2020; 45(1): 17-21.



Vancouver/ICMJE Style

Talpur MTH, Shabir KU, Shabir KU, Katbar MT, Yaqoob U, Kashif S. Antibiotic susceptibility pattern in an intensive care unit of a tertiary care hospital in Pakistan. RMJ. (2020), [cited December 10, 2023]; 45(1): 17-21.



Harvard Style

Talpur, M. T. H., Shabir, . K. U., Shabir, . K. U., Katbar, . M. T., Yaqoob, . U. & Kashif, . S. (2020) Antibiotic susceptibility pattern in an intensive care unit of a tertiary care hospital in Pakistan. RMJ, 45 (1), 17-21.



Turabian Style

Talpur, Mir Tahir Hussain, Kashif Ullah Shabir, Khalil Ullah Shabir, Muhammad Tauqeer Katbar, Uzair Yaqoob, and Shahida Kashif. 2020. Antibiotic susceptibility pattern in an intensive care unit of a tertiary care hospital in Pakistan. Rawal Medical Journal, 45 (1), 17-21.



Chicago Style

Talpur, Mir Tahir Hussain, Kashif Ullah Shabir, Khalil Ullah Shabir, Muhammad Tauqeer Katbar, Uzair Yaqoob, and Shahida Kashif. "Antibiotic susceptibility pattern in an intensive care unit of a tertiary care hospital in Pakistan." Rawal Medical Journal 45 (2020), 17-21.



MLA (The Modern Language Association) Style

Talpur, Mir Tahir Hussain, Kashif Ullah Shabir, Khalil Ullah Shabir, Muhammad Tauqeer Katbar, Uzair Yaqoob, and Shahida Kashif. "Antibiotic susceptibility pattern in an intensive care unit of a tertiary care hospital in Pakistan." Rawal Medical Journal 45.1 (2020), 17-21. Print.



APA (American Psychological Association) Style

Talpur, M. T. H., Shabir, . K. U., Shabir, . K. U., Katbar, . M. T., Yaqoob, . U. & Kashif, . S. (2020) Antibiotic susceptibility pattern in an intensive care unit of a tertiary care hospital in Pakistan. Rawal Medical Journal, 45 (1), 17-21.