Open Access and Peer-reviewed
Home Journal Issues Guide for Authors Editorial Board Aims & Scope About Journal News & Announcements


Original Research 


Antibiotic susceptibility pattern in an intensive care unit of a tertiary care hospital in Pakistan

Mir Tahir Hussain Talpur, Kashif Ullah Shabir, Khalil Ullah Shabir, Muhammad Tauqeer Katbar, Uzair Yaqoob, Shahida Kashif.

Abstract
Objective: To determine the most common microorganisms in the body secretions of patients admitted in an intensive care unit (ICU) of a tertiary care hospital and estimate antibiotic sensitivities to those organisms.
Methodology: In this cross-sectional study performed in the medical ICU of Jinnah Postgraduate Medical Center, Karachi, from January to February 2019, 95 specimens were collected from blood, endotracheal secretions, central catheter tips, and urine. Antibiotic sensitivity was tested by the disk diffusion method.
Results: Out of 95 patients, 69.5% were males and mean age was 27.3710 years. All patients had positive bacterial cultures except one that was of Candida albicans. Bacteria were mostly gram-negative (85.3%, n=81) and the most frequently encountered were Pseudomonas aeruginosa (34.7%). Pseudomonas aeruginosa was most sensitive to polymixin-B (17.8%, n=17). For Acinetobacter baumannii, colistin (10.5%, n=10) followed by cefoperazone/sulbactam (5.2%, n=5); for Klebsiella pneumoniae, amikacin and imipenem had equally highest sensitivity (8.4%, n=8). For Staphylococcus aureus, amikacin sensitivity was found in the majority (7.3%, n=7).
Conclusion: Microorganisms with multidrug-resistance especially gram-negative ones are increasing day by day. A high percentage of resistance to the frequently used antibiotics (cephalosporins, quinolones, and carbapenems) was found. The antibiotics prescribed empirically should be according to regularly updated antibiogram.

Key words: Culture, antibiotics, antibiotic resistance, multidrug resistance, antibiogram, intensive care units.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Mir Tahir Hussain Talpur
Articles by Kashif Ullah Shabir
Articles by Khalil Ullah Shabir
Articles by Muhammad Tauqeer Katbar
Articles by Uzair Yaqoob
Articles by Shahida Kashif
on Google
on Google Scholar
Article Statistics
 Viewed: 573
Downloaded: 2


How to Cite this Article
Pubmed Style

Talpur MTH, Shabir KU, Shabir KU, Katbar MT, Yaqoob U, Kashif S. Antibiotic susceptibility pattern in an intensive care unit of a tertiary care hospital in Pakistan. RMJ. 2020; 45(1): 17-21.


Web Style

Talpur MTH, Shabir KU, Shabir KU, Katbar MT, Yaqoob U, Kashif S. Antibiotic susceptibility pattern in an intensive care unit of a tertiary care hospital in Pakistan. http://www.rmj.org.pk/?mno=65776 [Access: March 29, 2020].


AMA (American Medical Association) Style

Talpur MTH, Shabir KU, Shabir KU, Katbar MT, Yaqoob U, Kashif S. Antibiotic susceptibility pattern in an intensive care unit of a tertiary care hospital in Pakistan. RMJ. 2020; 45(1): 17-21.



Vancouver/ICMJE Style

Talpur MTH, Shabir KU, Shabir KU, Katbar MT, Yaqoob U, Kashif S. Antibiotic susceptibility pattern in an intensive care unit of a tertiary care hospital in Pakistan. RMJ. (2020), [cited March 29, 2020]; 45(1): 17-21.



Harvard Style

Talpur, M. T. H., Shabir, . K. U., Shabir, . K. U., Katbar, . M. T., Yaqoob, . U. & Kashif, . S. (2020) Antibiotic susceptibility pattern in an intensive care unit of a tertiary care hospital in Pakistan. RMJ, 45 (1), 17-21.



Turabian Style

Talpur, Mir Tahir Hussain, Kashif Ullah Shabir, Khalil Ullah Shabir, Muhammad Tauqeer Katbar, Uzair Yaqoob, and Shahida Kashif. 2020. Antibiotic susceptibility pattern in an intensive care unit of a tertiary care hospital in Pakistan. Rawal Medical Journal, 45 (1), 17-21.



Chicago Style

Talpur, Mir Tahir Hussain, Kashif Ullah Shabir, Khalil Ullah Shabir, Muhammad Tauqeer Katbar, Uzair Yaqoob, and Shahida Kashif. "Antibiotic susceptibility pattern in an intensive care unit of a tertiary care hospital in Pakistan." Rawal Medical Journal 45 (2020), 17-21.



MLA (The Modern Language Association) Style

Talpur, Mir Tahir Hussain, Kashif Ullah Shabir, Khalil Ullah Shabir, Muhammad Tauqeer Katbar, Uzair Yaqoob, and Shahida Kashif. "Antibiotic susceptibility pattern in an intensive care unit of a tertiary care hospital in Pakistan." Rawal Medical Journal 45.1 (2020), 17-21. Print.



APA (American Psychological Association) Style

Talpur, M. T. H., Shabir, . K. U., Shabir, . K. U., Katbar, . M. T., Yaqoob, . U. & Kashif, . S. (2020) Antibiotic susceptibility pattern in an intensive care unit of a tertiary care hospital in Pakistan. Rawal Medical Journal, 45 (1), 17-21.








AUTHOR LOGIN

REVIEWER LOGIN

Indexed
&
Abstracted


Indexed in WHO Index Medicus IMEMR, Emromedex, Pakmedinet, ExtraMED and Scopus, Web of Science

  Approved by the Higher Education Commission of Pakistan and Pakistan Medical and Dental Council


ABOUT JOURNAL
POLICIES
STATEMENTS

This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author. This is in accordance with the Budapest Open Access Initiative (BOAI) definition of open access.

The articles in Rawal Medical Journal are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.