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Original Research 
RMJ. 2020; 45(1): 245-248


Frequency of histopathological subtypes of steroid resistant nephrotic syndrome among children below 12 years in a tertiary care hospital of Islamabad, Pakistan

Jai Krishin, Muqadar Shah, Shehzadi Sumbal Ghazi, Maqbool Hussain, Midhat Farzeen.

Abstract
Objective: To determine histological patterns of idiopathic steroid resistant nephrotic syndrome (SRNS) among children visiting Nephrology department of a tertiary care hospital in Pakistan.
Methodology: This cross-sectional observational retrospective study was conducted at Children’s Hospital, Pakistan Institute of Medical Sciences, Islamabad from April 2018 to May 2019. Data of 45 children under 12 years of age, presenting with steroid resistant nephrotic syndrome, who underwent renal biopsy were included in the study. Both light microscopy and immunofluorescence techniques were used. Age, gender, clinical indications, biochemical, urinary parameters and histopathological patterns were included in analysis.
Results: Out of 45 patients, 56% were males; age range was 10 months to 12 years (mean 3+1.2). The most prevalent histopathological pattern was Focal Segmental Glomerulosclerosis (FSGS), seen in 10 (22%) patients followed by Minimal Change Disease (MCD) in 9 (20%), Mesangial proliferative glomerulonephritis in 7 (15.5%) and IgM Nephropathy in 6 (13%) patients.
Conclusion: FSGS was the most common histological pattern underlying idiopathic SRNS among pediatric patients, followed by MCD in our study population.

Key words: Steroid resistant nephrotic syndrome, histopathology, children, FSGS.


 
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How to Cite this Article
Pubmed Style

Krishin J, Shah M, Ghazi SS, Hussain M, Farzeen M. Frequency of histopathological subtypes of steroid resistant nephrotic syndrome among children below 12 years in a tertiary care hospital of Islamabad, Pakistan. RMJ. 2020; 45(1): 245-248.


Web Style

Krishin J, Shah M, Ghazi SS, Hussain M, Farzeen M. Frequency of histopathological subtypes of steroid resistant nephrotic syndrome among children below 12 years in a tertiary care hospital of Islamabad, Pakistan. http://www.rmj.org.pk/?mno=55521 [Access: March 30, 2020].


AMA (American Medical Association) Style

Krishin J, Shah M, Ghazi SS, Hussain M, Farzeen M. Frequency of histopathological subtypes of steroid resistant nephrotic syndrome among children below 12 years in a tertiary care hospital of Islamabad, Pakistan. RMJ. 2020; 45(1): 245-248.



Vancouver/ICMJE Style

Krishin J, Shah M, Ghazi SS, Hussain M, Farzeen M. Frequency of histopathological subtypes of steroid resistant nephrotic syndrome among children below 12 years in a tertiary care hospital of Islamabad, Pakistan. RMJ. (2020), [cited March 30, 2020]; 45(1): 245-248.



Harvard Style

Krishin, J., Shah, . M., Ghazi, . S. S., Hussain, . M. & Farzeen, . M. (2020) Frequency of histopathological subtypes of steroid resistant nephrotic syndrome among children below 12 years in a tertiary care hospital of Islamabad, Pakistan. RMJ, 45 (1), 245-248.



Turabian Style

Krishin, Jai, Muqadar Shah, Shehzadi Sumbal Ghazi, Maqbool Hussain, and Midhat Farzeen. 2020. Frequency of histopathological subtypes of steroid resistant nephrotic syndrome among children below 12 years in a tertiary care hospital of Islamabad, Pakistan. Rawal Medical Journal, 45 (1), 245-248.



Chicago Style

Krishin, Jai, Muqadar Shah, Shehzadi Sumbal Ghazi, Maqbool Hussain, and Midhat Farzeen. "Frequency of histopathological subtypes of steroid resistant nephrotic syndrome among children below 12 years in a tertiary care hospital of Islamabad, Pakistan." Rawal Medical Journal 45 (2020), 245-248.



MLA (The Modern Language Association) Style

Krishin, Jai, Muqadar Shah, Shehzadi Sumbal Ghazi, Maqbool Hussain, and Midhat Farzeen. "Frequency of histopathological subtypes of steroid resistant nephrotic syndrome among children below 12 years in a tertiary care hospital of Islamabad, Pakistan." Rawal Medical Journal 45.1 (2020), 245-248. Print.



APA (American Psychological Association) Style

Krishin, J., Shah, . M., Ghazi, . S. S., Hussain, . M. & Farzeen, . M. (2020) Frequency of histopathological subtypes of steroid resistant nephrotic syndrome among children below 12 years in a tertiary care hospital of Islamabad, Pakistan. Rawal Medical Journal, 45 (1), 245-248.








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