Abstract
Objective: To determine the histopathological spectrum of nasal polyps across different age groups and both genders.
Methodology: This is cross-sectional retrospective study was carried out in Department of Histopathology of Liaquat National Hospital from 2012 to 2017. Hematoxylin and eosin (H&E) stained slides were examined with Immunohistochemistry selected cases. Variables like age, gender and laterality of lesion were recorded. The cases were broadly classified into neoplastic and non-neoplastic cases and neoplastic lesions were further classified according to the WHO classification. Descriptive statistical procedures were applied using SPSS 16.
Results: A total of 300 cases were seen during the study period. Non-neoplastic lesions were seen in 242(80.7%) and neoplastic in 78(19.4%) patients. Non- neoplastic inflammatory lesions were most common among 21-30 age group (n=79), while benign neoplastic lesions were most commonly seen in 51-60 age group (n=7). Malignant lesions were most common in 31-40 age group (n=10). Nasal polyps were twice more common in males (male=186 and females =94). Malignant neoplastic lesions are also more common in males (male=24 males and female=11). This was also seen in benign tumors i.e 23 cases (male=19 males and female=4).
Conclusion: Allergic/inflammatory nasal polyp was the most common pathology. Polyps most commonly were seen in second and third decade, and showed male predominance. In cases refractory to therapy, histopathological examination becomes essential for precise diagnosis and patient management.

Key words: Nose, Polypoidal Lesions, Benign, Malignant.