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Original Research 
RMJ. 2020; 45(1): 103-106


Is tranexamic acid really effective in the reducing the need for blood transfusion in patients undergoing Total Knee Replacement?

Jamal Suleiman Alshawabkeh, Laith Khaled Al-tarawneh, Mahdi Saleh Jaradat, Mohammad Ali Alsukour, Belal Mofreh Altarawneh.

Abstract
Objectives: To assess the efficacy of antifibrinolytic tranexamic acid (TXA) treatment in reducing preoperative and perioperative blood loss during total knee replacement (TKR).
Methodology: We reviewed the records of 57 patients who had undergone unilateral TKR between February and April, 2016. Mean age of patients was 62.4 (48-81) years and mean BMI was 33.14.7. Exclusion criteria included patients with renal impairment defined as serum creatinine higher than 1.4, history of venous thromboembolism or known coagulopathy, revision cases and patients whom their anesthesia was converted to general anesthesia. Surgeries were performed by a team of 3 surgeons following the same protocol in blood loss management. Patients were divided in 2 groups; TXA group (group A), 30 patients received it intravenously in 2 doses perioperatively, one given before incision and other on closure before tourniquet release and a non tranexamic acid group (group B), 27 patients were followed without receiving TXA. A standard venous thromboembolism prophylaxis was given for all patients. The primary outcome was the amount perioperative blood loss and level of hemoglobin 2 days postoperatively and venous thromboembolism were secondary outcomes.
Results: Transfusion rate was zero in Group A wen compared to the control group where 4 (8%) patients required transfusion (P<0.05). Hemoglobin change from preoperative reading after 24 hour and 48 hour postoperatively was 1.50.5 in group A and 2.80.5 in group B (P<0.001).
Conclusion: Preoperative and perioperative low doses of TXA were found to be safe, effective and easily accessible antifibrinolytic agent that significantly reduced blood loss and blood transfusion rate in patients undergoing TKR with no apparent increased risk of VTE.

Key words: Tranexamic Acid, Blood Transfusion, Total Knee Replacement.


 
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How to Cite this Article
Pubmed Style

Alshawabkeh JS, Al-tarawneh LK, Jaradat MS, Alsukour MA, Altarawneh BM. Is tranexamic acid really effective in the reducing the need for blood transfusion in patients undergoing Total Knee Replacement?. RMJ. 2020; 45(1): 103-106.


Web Style

Alshawabkeh JS, Al-tarawneh LK, Jaradat MS, Alsukour MA, Altarawneh BM. Is tranexamic acid really effective in the reducing the need for blood transfusion in patients undergoing Total Knee Replacement?. http://www.rmj.org.pk/?mno=39488 [Access: March 29, 2020].


AMA (American Medical Association) Style

Alshawabkeh JS, Al-tarawneh LK, Jaradat MS, Alsukour MA, Altarawneh BM. Is tranexamic acid really effective in the reducing the need for blood transfusion in patients undergoing Total Knee Replacement?. RMJ. 2020; 45(1): 103-106.



Vancouver/ICMJE Style

Alshawabkeh JS, Al-tarawneh LK, Jaradat MS, Alsukour MA, Altarawneh BM. Is tranexamic acid really effective in the reducing the need for blood transfusion in patients undergoing Total Knee Replacement?. RMJ. (2020), [cited March 29, 2020]; 45(1): 103-106.



Harvard Style

Alshawabkeh, J. S., Al-tarawneh, . L. K., Jaradat, . M. S., Alsukour, . M. A. & Altarawneh, . B. M. (2020) Is tranexamic acid really effective in the reducing the need for blood transfusion in patients undergoing Total Knee Replacement?. RMJ, 45 (1), 103-106.



Turabian Style

Alshawabkeh, Jamal Suleiman, Laith Khaled Al-tarawneh, Mahdi Saleh Jaradat, Mohammad Ali Alsukour, and Belal Mofreh Altarawneh. 2020. Is tranexamic acid really effective in the reducing the need for blood transfusion in patients undergoing Total Knee Replacement?. Rawal Medical Journal, 45 (1), 103-106.



Chicago Style

Alshawabkeh, Jamal Suleiman, Laith Khaled Al-tarawneh, Mahdi Saleh Jaradat, Mohammad Ali Alsukour, and Belal Mofreh Altarawneh. "Is tranexamic acid really effective in the reducing the need for blood transfusion in patients undergoing Total Knee Replacement?." Rawal Medical Journal 45 (2020), 103-106.



MLA (The Modern Language Association) Style

Alshawabkeh, Jamal Suleiman, Laith Khaled Al-tarawneh, Mahdi Saleh Jaradat, Mohammad Ali Alsukour, and Belal Mofreh Altarawneh. "Is tranexamic acid really effective in the reducing the need for blood transfusion in patients undergoing Total Knee Replacement?." Rawal Medical Journal 45.1 (2020), 103-106. Print.



APA (American Psychological Association) Style

Alshawabkeh, J. S., Al-tarawneh, . L. K., Jaradat, . M. S., Alsukour, . M. A. & Altarawneh, . B. M. (2020) Is tranexamic acid really effective in the reducing the need for blood transfusion in patients undergoing Total Knee Replacement?. Rawal Medical Journal, 45 (1), 103-106.








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