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RMJ. 2018; 43(4): 772-775


Hepatocytes of liver lobule are effected by Sodium arsenite and Lagenaria siceraria has protective role

Saima Qureshi, Khadija Qamar, Afnan Gul.

Abstract
Objective: To assess the effects of Lagenaria siceraria on arsenic induced fatty change in hepatocytes of liver.
Methodology: The study was done at Anatomy Department, Army Medical College Rawalpindi in collaboration with National Institute of Health (NIH) Islamabad for a period of eight weeks. Sprague Dawley rats (both male and female separately housed) were divided randomly into five groups each group indiscriminately had 10 animals. A and B served as untreated controls and C, D and E were experimental groups. Experimental groups were intervened with sodium arsenite to induce hepatotoxicity. Experimental group C was sacrificed after four weeks of arsenic intervention to observe immediate effects. In the next four weeks Group D was left without intervention to observe whether the toxic effects were self-limiting. Concomitant use of Lagenaria siceraria on group E along with arsenic was done. Liver specimens were stained with H & E and semi qualitative scoring of steatosis was done according to Brunt steatosis scoring. Data analysis was done by SPSS v 22.
Results: In group C animals, the fatty change (steatosis) was extensive and marked as compared to the control group A. Steatosis was also observed in the experimental groups D and E but it was less marked. In group E, the fatty change decreased extensively after the concomitant use of lagenaria siceraria (p≤0.05).
Conclusion: Administration of arsenic induced fatty changes in the hepatocytes. Concomitant use of Lagenaria siceraria mitigated these fatty changes in hepatocytes.

Key words: Sodium arsenite, steatosis, Lagenaria siceraria


 
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How to Cite this Article
Pubmed Style

Qureshi S, Qamar K, Gul A. Hepatocytes of liver lobule are effected by Sodium arsenite and Lagenaria siceraria has protective role. RMJ. 2018; 43(4): 772-775.


Web Style

Qureshi S, Qamar K, Gul A. Hepatocytes of liver lobule are effected by Sodium arsenite and Lagenaria siceraria has protective role. http://www.rmj.org.pk/?mno=293137 [Access: December 14, 2018].


AMA (American Medical Association) Style

Qureshi S, Qamar K, Gul A. Hepatocytes of liver lobule are effected by Sodium arsenite and Lagenaria siceraria has protective role. RMJ. 2018; 43(4): 772-775.



Vancouver/ICMJE Style

Qureshi S, Qamar K, Gul A. Hepatocytes of liver lobule are effected by Sodium arsenite and Lagenaria siceraria has protective role. RMJ. (2018), [cited December 14, 2018]; 43(4): 772-775.



Harvard Style

Qureshi, S., Qamar, . K. & Gul, . A. (2018) Hepatocytes of liver lobule are effected by Sodium arsenite and Lagenaria siceraria has protective role. RMJ, 43 (4), 772-775.



Turabian Style

Qureshi, Saima, Khadija Qamar, and Afnan Gul. 2018. Hepatocytes of liver lobule are effected by Sodium arsenite and Lagenaria siceraria has protective role. Rawal Medical Journal, 43 (4), 772-775.



Chicago Style

Qureshi, Saima, Khadija Qamar, and Afnan Gul. "Hepatocytes of liver lobule are effected by Sodium arsenite and Lagenaria siceraria has protective role." Rawal Medical Journal 43 (2018), 772-775.



MLA (The Modern Language Association) Style

Qureshi, Saima, Khadija Qamar, and Afnan Gul. "Hepatocytes of liver lobule are effected by Sodium arsenite and Lagenaria siceraria has protective role." Rawal Medical Journal 43.4 (2018), 772-775. Print.



APA (American Psychological Association) Style

Qureshi, S., Qamar, . K. & Gul, . A. (2018) Hepatocytes of liver lobule are effected by Sodium arsenite and Lagenaria siceraria has protective role. Rawal Medical Journal, 43 (4), 772-775.




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