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Original Research 
RMJ. 2019; 44(1): 216-219


Association study of Single Nucleotide Polymorphism rs4961 and dyslipidemia in hypertensive Rawalpindi/Islamabad population

Hamid Ali, Sadaf Jafar, Naveeda Zagham, Qurat-ul-Ain Zia, Maleha Asim.

Abstract
Objective: To evaluate the association between single nucleotide polymorphism rs4961 and dyslipidemia and to identify the odd ratio of allele to evaluate its significance.
Methodology: Deoxyribonucleic acid (DNA) samples from 200 patients with essential hypertension and 200 normotensive healthy individuals from Pakistani population were genotyped for SNP rs4961 by PCR and RFLP. DNA gel was used to establish the polymorphism profile belonging to genotype of SNP like GG, TG and TT in case of rs4961. Logistic regression analysis was used to find association between SNP rs4961 and dyslipidemia.
Results: The genotype frequencies for all three ADD1 genotype in disease subjects were 12.5% GG, 70.5% T/G and 34% T/T, respectively. The genotype frequencies for control subjects were 4% GG, 176% TG and 20% TT, respectively. Persons having heterozygous G/T or homozygous G/G genotype was 1.07 odds more risk of being dyslipidemia than subjects having T/T genotype showing significant association was found SNP rs4961 and dyslipidemia in hypertensives.
Conclusion: Single nucleotide polymorphism rs4961 has a significant association with dyslipidemia in hypertensive patients. SNP rs4961 may be a cause for dyslipidemia.

Key words: Dyslipidemia, Single nucleotide polymorphism, ADD1, PCR, RFLP, rs4961


 
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How to Cite this Article
Pubmed Style

Ali H, Jafar S, Zagham N, Zia Q, Asim M. Association study of Single Nucleotide Polymorphism rs4961 and dyslipidemia in hypertensive Rawalpindi/Islamabad population. RMJ. 2019; 44(1): 216-219.


Web Style

Ali H, Jafar S, Zagham N, Zia Q, Asim M. Association study of Single Nucleotide Polymorphism rs4961 and dyslipidemia in hypertensive Rawalpindi/Islamabad population. http://www.rmj.org.pk/?mno=289560 [Access: October 16, 2019].


AMA (American Medical Association) Style

Ali H, Jafar S, Zagham N, Zia Q, Asim M. Association study of Single Nucleotide Polymorphism rs4961 and dyslipidemia in hypertensive Rawalpindi/Islamabad population. RMJ. 2019; 44(1): 216-219.



Vancouver/ICMJE Style

Ali H, Jafar S, Zagham N, Zia Q, Asim M. Association study of Single Nucleotide Polymorphism rs4961 and dyslipidemia in hypertensive Rawalpindi/Islamabad population. RMJ. (2019), [cited October 16, 2019]; 44(1): 216-219.



Harvard Style

Ali, H., Jafar, . S., Zagham, . N., Zia, . Q. & Asim, . M. (2019) Association study of Single Nucleotide Polymorphism rs4961 and dyslipidemia in hypertensive Rawalpindi/Islamabad population. RMJ, 44 (1), 216-219.



Turabian Style

Ali, Hamid, Sadaf Jafar, Naveeda Zagham, Qurat-ul-Ain Zia, and Maleha Asim. 2019. Association study of Single Nucleotide Polymorphism rs4961 and dyslipidemia in hypertensive Rawalpindi/Islamabad population. Rawal Medical Journal, 44 (1), 216-219.



Chicago Style

Ali, Hamid, Sadaf Jafar, Naveeda Zagham, Qurat-ul-Ain Zia, and Maleha Asim. "Association study of Single Nucleotide Polymorphism rs4961 and dyslipidemia in hypertensive Rawalpindi/Islamabad population." Rawal Medical Journal 44 (2019), 216-219.



MLA (The Modern Language Association) Style

Ali, Hamid, Sadaf Jafar, Naveeda Zagham, Qurat-ul-Ain Zia, and Maleha Asim. "Association study of Single Nucleotide Polymorphism rs4961 and dyslipidemia in hypertensive Rawalpindi/Islamabad population." Rawal Medical Journal 44.1 (2019), 216-219. Print.



APA (American Psychological Association) Style

Ali, H., Jafar, . S., Zagham, . N., Zia, . Q. & Asim, . M. (2019) Association study of Single Nucleotide Polymorphism rs4961 and dyslipidemia in hypertensive Rawalpindi/Islamabad population. Rawal Medical Journal, 44 (1), 216-219.








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