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Original Research 
RMJ. 2018; 43(2): 324-327


Does isolation site of Enterobacteriaceae affect susceptibility against Imipenem?

Shehla Ambreen Alizai, Tariq Butt, Naila Rafique, Sania Waheed, Muhammad Roshan.

Abstract
Objective: To determine the susceptibility pattern of Enterobacteriaceae isolated from different body sites against Imipenem
Methodology: We conducted a retrospective analysis of the susceptibility pattern of
Enterobacteracaea against Imipenem, isolated from clinical specimens
between April 2014 to July 2017 at Rawal General and Dental hospital, Islamabad, Pakistan.
Results: A total of 575 Enterobacteriaceae were isolated from
urine, pus and other specimens. These specimens were taken from 163 males
and 412 females. The ages of patients ranged from 1 to 80 years.
Escherichia coli was among the most common isolate from all the specimens
(n=359), followed by Klebsiella pneumoniae (n=92) and Enterobacter cloacae
(n=51). Among the total isolates (n=575), 90.78% (n=522) were
susceptible to Imipenem. Isolates from urine revealed 95.52% susceptibility
against Imipenem which was significantly higher than the pus (74.22%) and
other specimens isolates (83.01%) susceptibility against Imipenem(p<0.0001).
Conclusion: The site of isolation appears to have a significant effect on the susceptibility of bacteria to Imipenem. This factor should be taken into account when considering antibiotic resistance. Overall Imipenem resistance (Carbapenemase Resistance Enterobacteriaceae) was less than 10% among Enterobacteriaceae in our set up. This resistance was lowest among
Enterobacteriaceae if isolated from urine (less than 5%).

Key words: Antibiotic Susceptibility, Enterobacteriaceae, Imipenem, site of isolation


 
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How to Cite this Article
Pubmed Style

Alizai SA, Butt T, Rafique N, Waheed S, Roshan M. Does isolation site of Enterobacteriaceae affect susceptibility against Imipenem?. RMJ. 2018; 43(2): 324-327.


Web Style

Alizai SA, Butt T, Rafique N, Waheed S, Roshan M. Does isolation site of Enterobacteriaceae affect susceptibility against Imipenem?. http://www.rmj.org.pk/?mno=278879 [Access: April 23, 2018].


AMA (American Medical Association) Style

Alizai SA, Butt T, Rafique N, Waheed S, Roshan M. Does isolation site of Enterobacteriaceae affect susceptibility against Imipenem?. RMJ. 2018; 43(2): 324-327.



Vancouver/ICMJE Style

Alizai SA, Butt T, Rafique N, Waheed S, Roshan M. Does isolation site of Enterobacteriaceae affect susceptibility against Imipenem?. RMJ. (2018), [cited April 23, 2018]; 43(2): 324-327.



Harvard Style

Alizai, S. A., Butt, T., Rafique, N., Waheed, S. & Roshan, M. (2018) Does isolation site of Enterobacteriaceae affect susceptibility against Imipenem?. RMJ, 43 (2), 324-327.



Turabian Style

Alizai, Shehla Ambreen, Tariq Butt, Naila Rafique, Sania Waheed, and Muhammad Roshan. 2018. Does isolation site of Enterobacteriaceae affect susceptibility against Imipenem?. Rawal Medical Journal, 43 (2), 324-327.



Chicago Style

Alizai, Shehla Ambreen, Tariq Butt, Naila Rafique, Sania Waheed, and Muhammad Roshan. "Does isolation site of Enterobacteriaceae affect susceptibility against Imipenem?." Rawal Medical Journal 43 (2018), 324-327.



MLA (The Modern Language Association) Style

Alizai, Shehla Ambreen, Tariq Butt, Naila Rafique, Sania Waheed, and Muhammad Roshan. "Does isolation site of Enterobacteriaceae affect susceptibility against Imipenem?." Rawal Medical Journal 43.2 (2018), 324-327. Print.



APA (American Psychological Association) Style

Alizai, S. A., Butt, T., Rafique, N., Waheed, S. & Roshan, M. (2018) Does isolation site of Enterobacteriaceae affect susceptibility against Imipenem?. Rawal Medical Journal, 43 (2), 324-327.




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