Open Access and Peer-reviewed
Home Journal Issues Guide for Authors Editorial Board Aims & Scope About Journal News & Announcements


Original Research 
RMJ. 2012; 37(4): 370-373


Pancytopenia: experience in a teriary care hospital of Peshawar, Pakistan.

Nazish Shinwari, Fazle Raziq, Khalid Khan, Farooq Taj Uppal, Hamzullah Khan.

Abstract
Objectives: To determine the causes of pancytopenia, in patients presenting to a tertiary care hospital of Peshawar.
Subject and methods: This cross sectional study was conducted in the department of pathology, Hayatabad Medical Complex, Peshawar, from Sept 2007 to February 2009. A total of hundred patients with established diagnosis of the pancytopenia were selected through non-probability sampling techniques. Relevant information’s were obtained from the patients with the help of a predesigned questionnaire prepared in accordance with the objectives of the study.
Results: Out of 455 patients who underwent bone marrow biopsies, 100 patients were selected who were fulfilling the inclusion criteria. Sixty four patients were males and 36 females. The age range f the patients was from <1 year up to 70 years with mean age 18 ± 15.8years.
Seventy two percent of patients presented with most common features of anemia. About (45%) patients presented with symptoms related to neutropenia and 35% presented with bleeding disorders and (19%) with patiechiel spots. Regarding risk assessment 3 (3%) patients had used antipyretics, antimalarials and antibiotics for long times for various disorders. Out of total 78% patients had a poor financial status. Blood transfusion history was found in 80% patients. Mean hemoglobin with SD was 6.8+ 1.8. mean leukocytes count was mean was 2818.77/cmm with SD + 3746.97. Mean platelet count was 44040.0 with SD + 43318.86.Mean reticulocyte count of 1.76 with SD + 1.98.
Megaloblastic anemia contributed n=27 (27%) cases Out of total (18%) were ALL and 5 (05%) cases were AML. Aplastic anemia was recorded in (21%) cases. Fourth cause in descending order was hypersplenism 11% and visceral leishmaniasis was noted in 8%.

Conclusion: Pancytopenia is an important clinical problem, occurring more common in males. Megaloblastic anemia and malignant causes are major contributor to pancytpenia in our set up. Bone-marrow examination is an established diagnostic modality. The common causes of pancytopenia in our community, are completely curable while others can be treated to reduce morbidity and prolong survival.

Key words: Pancytopenia, Megaloblastic anaemia, Aplastic anaemia.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Nazish Shinwari
Articles by Fazle Raziq
Articles by Khalid Khan
Articles by Farooq Taj Uppal
Articles by Hamzullah Khan
on Google
on Google Scholar
Article Statistics
 Viewed: 4184
Downloaded: 647
Cited: 0


REFERENCES
1. Ishtaiq O, Baqai HZ, Anwar F, Hussain N. Patterns of Pancytopenia patients in a general medical ward and a proposed diagnostic approach. J Ayub Med Coll Abboottabad 2004;16(1):8-13.
2. Bates I, Bain BJ. Approach to diagnosis and classification of blood diseases, In Lewis SM, Bain BJ, Bates I, editors. Practical Haematology, 10th ed. Elsevier Churchill livingstone. Philadelphia, 2006: 615.
3. Niazi M, Raziq F. The incidence of underlying pathology in pancytopenia-an experience of 89 cases Journal Postgraduate Medical Institute 2004; 18(1) :76-79.
4. Rehman H, Fazil M, Mohammad F. Clinical presentation of pancytopenia in children under 15 years of age. Journal Postgraduate Medical Institute 2003;17(1): 46-51.
5. Bhatnagar SK, Chandra J, Narayan S, Sharma S, Singh V, Dutta AK. Pancytopenia in children:etiological profile. J Trop pediatr 2005; 51(4):236-9. [DOI via Crossref]    [Pubmed]   
6. Gupta V, Tripathi S, Tilak V, Bhatia BD. A study of clinico-hematological profile of pancytopenia in children. Trop Doct 2008;38(4): 241-3. [DOI via Crossref]    [Pubmed]   
7. Halfdanarson TR, Walker JA, Litzow MR, Hanson CA. Severe B12 deficiency resulting in pancytopenia, splenomegaly and leucoerythroblastosis. European Journal of Hematology ISSN 0902-4441 2008; 80(5): 448-51. [DOI via Crossref]    [Pubmed]   
8. Hobeika EM, Usta IM, Taher AT, Nassar AH. Splenomegaly, pancytopenia and pregnancy, a case report and review of literature. J Infect 2005; 51(5): 273-5. [DOI via Crossref]    [Pubmed]   
9. Brodsky RA, Jones RJ. Aplastic anemia. Lancet 2005;365(9471):1647-56. [DOI via Crossref]   
10. Yang CP, Kuo MC, Guh JY, Chen HC. Pancytopenia after low dose methotrexate therapy in a hemodialysis patient:case report and review of literature. Ren Fail 2006;28(1):95-7. [DOI via Crossref]    [Pubmed]   
11. Dokal I, Vulliamy T. Inherited aplastic anaemia/ bone-marrow failure syndromes. Blood Rev 2008; 22(3):141-53. [DOI via Crossref]    [Pubmed]   
12. Rahim F, Ahmad I, Islam S, Hussain M, Khattak TAK, Bano Q. Spectrum of heamatological disorders in chidren. Obsserved in 424 consecutive bone-marrow aspirations / biopsies. Pak J of Med Sciences 2005; 21(4): 433-36.
13. Khodke K, Marwah S, Buxi G, Yadav RB, Chaturvedi NK. Bone-marrow examination in cases of pancytopenia. J Indian Academy of Clinical Medicine 2001; 2(1,2):55-9.
14. Hamid GA, Shukry SAR. Patterns of panytopenia in Yemen. Turk J Hematol 2008; 25:71-4.
15. Memon S, Shaikh S, Nizamani MAA. Etiological spectrum of pancytopenia based on bone-marrow examination in children. J College of Physicians and Surgeons Pak 2008;18(3):163-67.
16. Qazi RA, Masood A. Diagnostic evaluation of pancytopenia. J Rawal Med Coll 2002;6(1):30-3.
17. Rahim F, Ahmad I, Islam S, Hussain M, Khattak TAK, Bano Q. Spectrum of heamatological disorders in chidren. Obsserved in 424 consecutive bone-marrow aspirations / biopsies. Pak J of Med Sciences 2005; 21(4): 433-36
18. Jha A, Sayami G, Adhikari RC, Panta AD, Jha R. Bone-marrow examination in cases of pancytopenia. J Nepal Med Assoc 2008; 47(169): 12-7

How to Cite this Article
Pubmed Style

Nazish Shinwari, Fazle Raziq, Khalid Khan, Farooq Taj Uppal, Hamzullah Khan. Pancytopenia: experience in a teriary care hospital of Peshawar, Pakistan.. RMJ. 2012; 37(4): 370-373.


Web Style

Nazish Shinwari, Fazle Raziq, Khalid Khan, Farooq Taj Uppal, Hamzullah Khan. Pancytopenia: experience in a teriary care hospital of Peshawar, Pakistan.. http://www.rmj.org.pk/?mno=15560 [Access: March 22, 2019].


AMA (American Medical Association) Style

Nazish Shinwari, Fazle Raziq, Khalid Khan, Farooq Taj Uppal, Hamzullah Khan. Pancytopenia: experience in a teriary care hospital of Peshawar, Pakistan.. RMJ. 2012; 37(4): 370-373.



Vancouver/ICMJE Style

Nazish Shinwari, Fazle Raziq, Khalid Khan, Farooq Taj Uppal, Hamzullah Khan. Pancytopenia: experience in a teriary care hospital of Peshawar, Pakistan.. RMJ. (2012), [cited March 22, 2019]; 37(4): 370-373.



Harvard Style

Nazish Shinwari, Fazle Raziq, Khalid Khan, Farooq Taj Uppal, Hamzullah Khan (2012) Pancytopenia: experience in a teriary care hospital of Peshawar, Pakistan.. RMJ, 37 (4), 370-373.



Turabian Style

Nazish Shinwari, Fazle Raziq, Khalid Khan, Farooq Taj Uppal, Hamzullah Khan. 2012. Pancytopenia: experience in a teriary care hospital of Peshawar, Pakistan.. Rawal Medical Journal, 37 (4), 370-373.



Chicago Style

Nazish Shinwari, Fazle Raziq, Khalid Khan, Farooq Taj Uppal, Hamzullah Khan. "Pancytopenia: experience in a teriary care hospital of Peshawar, Pakistan.." Rawal Medical Journal 37 (2012), 370-373.



MLA (The Modern Language Association) Style

Nazish Shinwari, Fazle Raziq, Khalid Khan, Farooq Taj Uppal, Hamzullah Khan. "Pancytopenia: experience in a teriary care hospital of Peshawar, Pakistan.." Rawal Medical Journal 37.4 (2012), 370-373. Print.



APA (American Psychological Association) Style

Nazish Shinwari, Fazle Raziq, Khalid Khan, Farooq Taj Uppal, Hamzullah Khan (2012) Pancytopenia: experience in a teriary care hospital of Peshawar, Pakistan.. Rawal Medical Journal, 37 (4), 370-373.








AUTHOR LOGIN

REVIEWER LOGIN

Indexed
&
Abstracted


Indexed in WHO Index Medicus IMEMR, Emromedex, Pakmedinet, ExtraMED and Scopus

  Approved by the Higher Education Commission of Pakistan and Pakistan Medical and Dental Council


ABOUT JOURNAL
POLICIES
STATEMENTS

This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author. This is in accordance with the Budapest Open Access Initiative (BOAI) definition of open access.

The articles in Rawal Medical Journal are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.