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Original Research 
RMJ. 2020; 45(4): 775-779


Emerging pattern of bacterial isolates causing neonatal sepsis and their antibiotic susceptibility

Muhammad Adnan, Amna Khan, Ammara Khalid, Sajjad Ahmad Khan, Ifnan Shamraiz, Khyal Muhammad.

Abstract
Objective: To find the bacterial isolates causing neonatal sepsis and their antibiotic susceptibility patterns.
Methodology: This cross-sectional observational study was done at Department of Pediatrics, Ayub Teaching Hospital, Abbottabad, from June to December 2019. A total of 84 confirmed blood culture positive cases of both genders, aged <28 days and admitted with neonatal sepsis were enrolled. Identified organisms were tested against commonly used antibiotics for susceptibility patterns.
Results: Out of a total of 84 neonates, 54 (64.3%) were boys and 30 (35.7%) girls. Most (50; 59.5%) had gram positive bacterial isolates. Most commonly involved gram positive isolates were Staphylococcus aureus (23; 46.0%) while Klebsiella pneumoniae was the commonest gram negative isolate, found in 13 (38.2%) cases. Overall, causative agent isolates showed highest antimicrobial sensitivity patterns for Linezolid (91.5%), Amikacin (90.8%), Clindamycin (89.5%), Piperacillin Tazobactum (84.8%) and Vancomycin (80.6%) while Amoxicillin (80.8%), Ampicillin (79.7%), Cefotaxime (70.7%) and Ceftriaxone (69.9%) had highest rates of resistance.
Conclusion: Staphylococcus aureus, Staplhylococcus epidermidis and Klebsiella pneumonia were the commonest causative agent for neonatal sepsis. Routinely used empirical antibiotics like Cefotaxime, Ceftriaxone, Ampicillin and Amoxicillin had high rates of resistance.

Key words: Neonatal sepsis, causative agent, antibiotic susceptibility.


 
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How to Cite this Article
Pubmed Style

Adnan M, Khan A, Khalid A, Khan SA, Shamraiz I, Muhammad K. Emerging pattern of bacterial isolates causing neonatal sepsis and their antibiotic susceptibility. RMJ. 2020; 45(4): 775-779.


Web Style

Adnan M, Khan A, Khalid A, Khan SA, Shamraiz I, Muhammad K. Emerging pattern of bacterial isolates causing neonatal sepsis and their antibiotic susceptibility. http://www.rmj.org.pk/?mno=123001 [Access: December 18, 2020].


AMA (American Medical Association) Style

Adnan M, Khan A, Khalid A, Khan SA, Shamraiz I, Muhammad K. Emerging pattern of bacterial isolates causing neonatal sepsis and their antibiotic susceptibility. RMJ. 2020; 45(4): 775-779.



Vancouver/ICMJE Style

Adnan M, Khan A, Khalid A, Khan SA, Shamraiz I, Muhammad K. Emerging pattern of bacterial isolates causing neonatal sepsis and their antibiotic susceptibility. RMJ. (2020), [cited December 18, 2020]; 45(4): 775-779.



Harvard Style

Adnan, M., Khan, . A., Khalid, . A., Khan, . S. A., Shamraiz, . I. & Muhammad, . K. (2020) Emerging pattern of bacterial isolates causing neonatal sepsis and their antibiotic susceptibility. RMJ, 45 (4), 775-779.



Turabian Style

Adnan, Muhammad, Amna Khan, Ammara Khalid, Sajjad Ahmad Khan, Ifnan Shamraiz, and Khyal Muhammad. 2020. Emerging pattern of bacterial isolates causing neonatal sepsis and their antibiotic susceptibility. Rawal Medical Journal, 45 (4), 775-779.



Chicago Style

Adnan, Muhammad, Amna Khan, Ammara Khalid, Sajjad Ahmad Khan, Ifnan Shamraiz, and Khyal Muhammad. "Emerging pattern of bacterial isolates causing neonatal sepsis and their antibiotic susceptibility." Rawal Medical Journal 45 (2020), 775-779.



MLA (The Modern Language Association) Style

Adnan, Muhammad, Amna Khan, Ammara Khalid, Sajjad Ahmad Khan, Ifnan Shamraiz, and Khyal Muhammad. "Emerging pattern of bacterial isolates causing neonatal sepsis and their antibiotic susceptibility." Rawal Medical Journal 45.4 (2020), 775-779. Print.



APA (American Psychological Association) Style

Adnan, M., Khan, . A., Khalid, . A., Khan, . S. A., Shamraiz, . I. & Muhammad, . K. (2020) Emerging pattern of bacterial isolates causing neonatal sepsis and their antibiotic susceptibility. Rawal Medical Journal, 45 (4), 775-779.








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