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Original Research 
RMJ. 2020; 45(3): 537-540


Frequency of HER-2 positive and expression pattern in gastric adenocarcinoma by immunohistochemistry.

Shahnawar Gulzar, Nadira Mamoon, Imran Nazir, Zafar Ali.

Abstract
Objective: To determine the frequency and expression of HER2/neupositivity by immunohistochemistry in gastric adenocarcinoma.
Methodology: A total of 68 cases of gastric adenocarcinoma were included and Immunohistochemical marker for HER2/neu was applied and evaluated on paraffin sections. HER2/neu overexpression according to age, gender, site and histological type was determined. HER2/neu was assessed on the membrane staining of tumor cells. It was considered positive when more than 10% of the cells stained positively in resection specimens and for biopsy specimens at least 5 cells were positive.
Results:Out of 68 cases, 42 (61.8%) were gastric cardia in origin, 16 (23.5%) of gastoesophageal junction and 10 (14.7%) of gastric fundus. 3+ HER2/neu staining in gastric cardia, gastroesophageal junction and gastric fundus was found to be 6 (14.3%), 6 (37.5%) and 2 (20%), respectively. 36 (52.9%) cases were intestinal type and 32 (47.1%) were signet ring type and 3+ HER2/neu staining was 12 (33.3%), and 2 (6.3%), respectively. There were 3+ positive in 14 (20.6%) cases, 0, 1+ negative in 38 (55.9%) cases and 2+ equivocal in 16 (23.5%).
Conclusion: HER2/neuoverexpression can be determined in gastric adenocarcinoma by using immunohistochemistry. Approximately 21% cases showed overexpression in our study. Larger studies are required for more definitive results to accurately determine proportion of patients who may benefit from trastuzumab therapy.

Key words: Gastric adenocarcinoma, HER2 /neu, Immunohistochemistry.


 
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How to Cite this Article
Pubmed Style

Gulzar S, Mamoon N, Nazir I, Ali Z. Frequency of HER-2 positive and expression pattern in gastric adenocarcinoma by immunohistochemistry.. RMJ. 2020; 45(3): 537-540.


Web Style

Gulzar S, Mamoon N, Nazir I, Ali Z. Frequency of HER-2 positive and expression pattern in gastric adenocarcinoma by immunohistochemistry.. http://www.rmj.org.pk/?mno=100613 [Access: September 02, 2020].


AMA (American Medical Association) Style

Gulzar S, Mamoon N, Nazir I, Ali Z. Frequency of HER-2 positive and expression pattern in gastric adenocarcinoma by immunohistochemistry.. RMJ. 2020; 45(3): 537-540.



Vancouver/ICMJE Style

Gulzar S, Mamoon N, Nazir I, Ali Z. Frequency of HER-2 positive and expression pattern in gastric adenocarcinoma by immunohistochemistry.. RMJ. (2020), [cited September 02, 2020]; 45(3): 537-540.



Harvard Style

Gulzar, S., Mamoon, . N., Nazir, . I. & Ali, . Z. (2020) Frequency of HER-2 positive and expression pattern in gastric adenocarcinoma by immunohistochemistry.. RMJ, 45 (3), 537-540.



Turabian Style

Gulzar, Shahnawar, Nadira Mamoon, Imran Nazir, and Zafar Ali. 2020. Frequency of HER-2 positive and expression pattern in gastric adenocarcinoma by immunohistochemistry.. Rawal Medical Journal, 45 (3), 537-540.



Chicago Style

Gulzar, Shahnawar, Nadira Mamoon, Imran Nazir, and Zafar Ali. "Frequency of HER-2 positive and expression pattern in gastric adenocarcinoma by immunohistochemistry.." Rawal Medical Journal 45 (2020), 537-540.



MLA (The Modern Language Association) Style

Gulzar, Shahnawar, Nadira Mamoon, Imran Nazir, and Zafar Ali. "Frequency of HER-2 positive and expression pattern in gastric adenocarcinoma by immunohistochemistry.." Rawal Medical Journal 45.3 (2020), 537-540. Print.



APA (American Psychological Association) Style

Gulzar, S., Mamoon, . N., Nazir, . I. & Ali, . Z. (2020) Frequency of HER-2 positive and expression pattern in gastric adenocarcinoma by immunohistochemistry.. Rawal Medical Journal, 45 (3), 537-540.








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